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About the Role
Genentech's Investigative Toxicology group seeks an experienced individual contributor to drive the strategy, development, and implementation of predictive and mechanistic safety capabilities for Neuroscience and Cardiovascular, Renal, and Metabolic (CVRM) portfolios. This role involves establishing preclinical safety roadmaps for emerging therapeutic modalities, interfacing with cross-functional teams, and advancing New Approach Methodologies (NAMs).
Responsibilities
- Serve as the primary Investigative Toxicology subject matter expert on discovery and early development project teams.
- Apply knowledge of drug discovery/development workflows to identify safety liabilities and influence candidate selection.
- Guide nonclinical safety strategies and mechanistic de-risking plans with Project Team Toxicologists, Discovery Scientists, and Pathologists.
- Establish, qualify, and execute preclinical safety roadmaps for novel and emerging therapeutic modalities.
- Identify technological gaps and design innovative solutions for characterizing on-target and exaggerated pharmacology liabilities.
- Drive the strategic identification, validation, and implementation of next-generation capability needs for Neuro and CVRM safety assessment.
- Lead scientific strategy and oversee complex experimental studies using matrixed support from Investigative Toxicology wet-lab members.
- Ensure rigorous data integrity, thorough electronic laboratory notebook documentation, and publication-ready technical reports.
- Partner with Predictive Toxicology colleagues to establish translatable, predictive workflows.
- Co-develop and implement human-relevant cellular systems to tailor assay platforms to project-specific liabilities.
- Represent the Investigative Toxicology group and Genentech in key external industry, academic, and regulatory consortia.
- Spearhead external engagement and publication efforts around the qualification and regulatory adoption of New Approach Methodologies (NAMs).
Requirements
- Ph.D. with 3-5+ years of relevant postdoctoral or industry experience (Principal Scientist) or Ph.D. with >5+ years of industry experience demonstrating successful safety leadership and cross-functional impact (Senior Principal Scientist).
- Proven track record of operating within a drug discovery/development setting.
- Demonstrated ability to identify, prioritize, and de-risk rate-limiting liabilities.
- Prior experience working with emerging therapeutic modalities and developing custom preclinical safety strategies.
- Demonstrated ability to lead via influence in a matrixed environment, guiding experimental work executed by laboratory technical staff.
- Exceptional oral and written communication skills.
- Ability to distill complex mechanistic toxicology data into actionable project team recommendations.
- Willingness and ability to represent Genentech authoritatively in external scientific working groups and consortia.
Skills
- Mechanistic understanding of safety assessment, cellular pathways, and organ-level physiology relevant to Neuroscience and/or CVRM.
- Familiarity with advanced in vitro models, microphysiological systems (MPS / organ-on-a-chip), iPSC technologies, high-content phenotypic assays, and multi-omics/transcriptomics.
- Experience collaborating with computational biologists and predictive modelers to interpret complex datasets.
- Proficiency with statistical and data visualization tools (e.g., GraphPad Prism, Spotfire, JMP, R, or Python).
Location
- San Francisco, CA
Work Type
- Full-time
Experience Level
- Principal Scientist: 3-5+ years postdoctoral or industry experience
- Senior Principal Scientist: >5+ years industry experience
Education Level
- Ph.D.
Salary/Compensations
- $141,500.00 - $262,900.00 (Principal Scientist)
- $173,100.00 - $321,500.00 (Senior Principal Scientist)
Benefits
- Relocation Assistance
- Discretionary annual bonus
- Detailed benefits package available
About the Company
- Genentech advances science so that we all have more time with the people we love.
- The Investigative Toxicology group within the Translational Safety department is dedicated to elucidating the underlying mechanisms of toxicities for novel therapeutics from drug discovery through clinical development.
- The group provides fit-for-purpose solutions using state-of-the-science in vitro and ex vivo experimental approaches to address target safety assessments, guide lead optimization, and de-convolute complex safety liabilities.
Equal Opportunity
- Genentech is an equal opportunity employer.
- It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.
- The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
- If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.