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About the Role
The Scientist II, Discovery Biology is an experienced, hands-on discovery scientist who leads key experimental workstreams supporting the evaluation and advancement of therapeutic opportunities. The role independently frames scientific questions, identifies risks, develops and executes studies, builds assays, and synthesizes data to influence target-selection and program-initiation decisions. This role provides scientific leadership, coordinates contributions from other scientists, and offers mentorship to junior scientists. The Scientist II participates in discussions with executive, clinical, and commercial stakeholders to understand how discovery evidence informs program strategy.
Responsibilities
- Critically evaluates scientific literature, frames key questions, and develops integrated, hypothesis-driven experimental strategies to evaluate novel therapeutic targets.
- Leads key target-identification and target-validation workstreams and integrates scientific activities across functions to advance therapeutics opportunities toward target-selection and program-initiation decisions.
- Independently designs, develops, executes, and troubleshoots cellular, biochemical, and immunological assays and applies sound scientific judgment to complex experimental problems.
- Integrates, analyzes, interprets, and communicates complex data to influence technical direction and recommend project advancement, termination, or next steps.
- Influences technical direction across cross-functional discovery activities by integrating Discovery Biology findings with input from partner functions.
- Identifies scientific, technical, and execution risks within assigned workstreams, develops practical mitigation plans, and escalates broader program-level risks when appropriate.
- Coordinates and aligns internal and external scientific resources to ensure delivery of assigned studies, including working with Protein Production, In Vitro Biology, Translational R&D, collaborators, vendors, and contract research organizations.
- Participates in clinical and commercial discussions, with appropriate senior leadership involvement, and incorporates relevant input into discovery hypotheses, experimental strategies, and data interpretation.
- Provides ongoing scientific guidance and mentorship to junior scientists, including review of experimental plans, controls, data quality, and conclusions.
- Contributes to invention disclosures, patents, research reports, publications, and other high-quality scientific documentation; presents findings internally and may present at company-level or external forums.
- Maintains high-quality scientific documentation and follows applicable research and data-integrity standards.
- Performs other duties as assigned.
Requirements
- Demonstrated ability to independently lead scientific research workstreams and collaborate across functions.
- Experience in accessing, compiling and analyzing publicly available datasets from multiple sources in support of the relevancy of targets within disease indications.
- Strong understanding of drug development, disease biology, immunology, cellular biology, biochemistry, and target validation.
- Technical expertise across cellular, biochemical, and immunological assays, including immunoassays, activity assays, biomarker assays, and cell-activation assays.
- Experience with several relevant methods such as siRNA, qPCR, flow cytometry, cell purification, cellular imaging, immunohistochemistry, or immunofluorescence.
- Ability to critically evaluate scientific literature, select feasible experimental approaches, and design studies with appropriate controls and decision criteria.
- Deep and broad experience in assay development, experimental design, troubleshooting, data analysis, and efficient execution.
- Ability to influence technical direction across functions by integrating Discovery Biology findings, discovery objectives, and cross-functional scientific input.
- Ability to coordinate technical work, provide constructive scientific feedback, and support accountability without always relying on formal authority.
- Strong communication skills and the ability to present complex data clearly to cross-functional teams, senior leaders, and external partners.
- Ability to prioritize multiple project workstreams and incorporate relevant clinical and commercial considerations affect discovery strategy.
Skills
- Drug development
- Disease biology
- Immunology
- Cellular biology
- Biochemistry
- Target validation
- Immunoassays
- Activity assays
- Biomarker assays
- Cell-activation assays
- siRNA
- qPCR
- Flow cytometry
- Cell purification
- Cellular imaging
- Immunohistochemistry
- Immunofluorescence
- Assay development
- Experimental design
- Troubleshooting
- Data analysis
- Communication
Location
- South San Francisco, CA
Work Type
- Full-time
- Onsite
Experience Level
- 2 to 5 years of relevant experience (Ph.D.)
- 10 or more years of relevant experience (M.S.)
- 12 or more years of relevant experience (B.S.)
Education Level
- Ph.D. in immunology, autoimmune disease, molecular biology, or a related scientific discipline
- M.S.
- B.S.
Salary/Compensations
- $120,000 to $150,000 annually
Benefits
- Bonus
- Benefits package
- Participation in Company’s equity plan
About the Company
- Star Therapeutics is a biotechnology company that aims to discover and develop best-in-class antibody therapies to transform the lives of patients with serious diseases.
- Founded by former True North executives, Star has built a team with significant scientific expertise that has a demonstrated track record of success and is backed by top-tier biotech investors.
- We pride ourselves on our collective passion in bringing innovative therapies to the clinic and are committed to patients for whom no or limited treatment options exist.
- Star is headquartered in South San Francisco, CA.
- Star offers a competitive salary and benefits package, and we take pride on being a Biocom Best Place to Work for small companies.
- We’re also a company where you can flourish and grow your career, learn and explore, and make connections.
Equal Opportunity
- We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender identity, sexual orientation, age, marital status, veteran status, or disability status.