Senior Scientist, Protein & Peptide/Chemical-Protein Conjugate Formulation
JLSa2 Therapeutics · CA, US
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About the Role
JLSa2 is seeking a Senior Protein & Peptide/Chemical-Protein Conjugate Formulation Scientist to lead the development, optimization, and characterization of stable formulations for protein- and peptide/chemical conjugates-based therapeutics. This role requires expertise in biophysical characterization, formulation design, and stability strategy to support programs from discovery through clinical development, combining hands-on work with technical leadership and strategic input.
Responsibilities
- Design and optimize formulations for proteins and peptide/chemical-protein conjugates (liquid, long-acting, oral and high-concentration)
- Develop formulation strategies that address stability, aggregation, degradation, and delivery challenges
- Support route of administration and dosage form selection for subcutaneous and oral routes
- Lead formulation risk assessments and mitigation strategies
- Apply biophysical techniques to assess stability and developability (e.g., DSC, DLS, CD, SEC, HIC, rheology, subvisible particles)
- Interpret stress and forced degradation data to guide formulation decisions
- Collaborate with analytical teams on method development and comparability
- Serve as formulation lead on cross-functional project teams
- Provide formulation input to candidate selection and early CMC strategy
- Support tech transfer to development, manufacturing, and external partners
- Contribute to IND-enabling and regulatory documentation (CMC sections)
- Mentor junior formulation and analytical scientists
- Establish best practices, workflows, and technical standards
- Act as a subject-matter expert in internal reviews and governance forums
- Manage and oversee formulation activities with CROs and CDMOs
- Evaluate new formulation technologies and excipient strategies
- Stay current with advances in protein and peptide formulation science
Requirements
- PhD in pharmaceutical sciences, chemical engineering, biochemistry, or related discipline
- 5–10+ years of industry experience in protein and/or peptide formulation
- Deep expertise in biologics and drug-conjugates formulation and stability science
- Experience with high-concentration formulations and/or long-acting injectables
- Experience with oral delivery formulations
- Proven track record supporting clinical candidates
- Strong experimental design, data interpretation, and problem-solving skills
- Familiarity with device compatibility and combination products
- Familiarity with Auntie and Big Tuna and other Unchained analytical tools
- Experience with global regulatory filings (IND/IMPD)
- Prior experience in biotech or fast-paced development environments
- Scientific rigor and technical depth
- Cross-functional leadership without direct authority
- Strategic thinking with hands-on execution
- Clear scientific communication and documentation
- Mentorship and team development
Skills
- Biophysical characterization
- Formulation design
- Stability strategy
- Protein formulation
- Peptide formulation
- Chemical-protein conjugate formulation
- Liquid formulation
- Long-acting formulation
- Oral formulation
- High-concentration formulation
- Subcutaneous delivery
- Oral delivery
- DSC
- DLS
- CD
- SEC
- HIC
- Rheology
- Subvisible particle analysis
- Method development
- Comparability studies
- Tech transfer
- IND-enabling documentation
- Regulatory documentation (CMC)
- CRO/CDMO management
- Excipient strategy
Location
- South San Francisco
Work Type
- Full-time
Experience Level
- Senior
- 5-10+ years industry experience
Education Level
- PhD
Salary/Compensations
- $175,000 to $200,000+
About the Company
- JLSa2, founded in 2024, is a well-resourced, seed-stage venture backed company.
- The company is developing a robust pipeline of novel protein-drug conjugate therapies.
- JLSa2 focuses on addressing human metabolic diseases and other non-oncology related diseases.