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About the Role
TCG Labs Soleil is seeking an expert and engaged Associate Director / Director, Analytical Characterization to lead analytical and biophysical characterization efforts within the Protein Sciences group of the Biologics Technology team. This role provides strategic vision and oversight for developability assessments, analytical characterization, and method strategy across the biologics portfolio. The position involves leading from the bench to generate critical data for decision-making in candidate selection and due diligence, leading and mentoring a scientific team, and driving the adoption of novel analytical technologies.
Responsibilities
- Prepare developability assessments packages for biologic candidates, evaluating stability, solubility, aggregation, post-translational modifications, manufacturability, and risk factors.
- Design, develop, validate, and execute analytical and biophysical methods to characterize therapeutic proteins and antibodies throughout the preclinical pipeline.
- Lead from the bench, utilizing technical expertise to conduct experimental setups and troubleshoot complex issues.
- Serve as the analytical lead in due diligence and business development contexts: evaluate external data, review analytical packages, identify technical risk, and advise decision-makers.
- Manage CROs and external collaborations for method development, validation, tech transfer, and analytical support ensuring quality, timelines, and cost efficiency.
- Evaluate emerging analytical technologies for feasibility, cost-effectiveness, and performance; guide their adoption to enhance throughput, sensitivity, and risk mitigation.
- Mentor and manage a high-performing analytical team; set scientific and operational priorities, ensure training, help with professional development.
- Collaborate closely with CMC to align analytical strategies with formulation and process development.
Requirements
- Ph.D. or equivalent in a related discipline with 8+ years' experience in monoclonal and multi-specific antibody characterization in an industry setting, preferably startup or biotechnology companies.
- Proven leadership experience with a track record of managing direct reports and mentoring scientific teams.
- Strong understanding of protein analytical principles and methodologies.
- Extensive experience in characterizing biologics post-translational modifications (PTMs).
- In-depth knowledge of attributes of protein therapeutic drug candidates.
- Extensive hands-on experience in developability studies for antibody therapeutics.
- Deep understanding of biologics drug discovery process, particularly hit-to-lead, lead optimization, and candidate selection.
- Research-driven mindset with a focus on therapeutic development.
- Familiarity with CMC development process; prior experience with Investigational New Drug (IND) filing required.
- Meticulous in data organization; capable of multitasking and managing multiple projects without compromising quality.
- Excellent oral and written communication skills.
- Strong team-working skills; adaptable and quick to learn new techniques.
- Ability to thrive and deliver results in a fast-paced, dynamic environment.
Skills
- HPLC
- CE
- SPR
- DSF
- DSC
- SEC-MALS
- LC-MS
- Analytical characterization
- Biophysical characterization
- Method development
- Method validation
- Protein characterization
- Antibody characterization
- Developability assessments
- Data analysis
- Project management
- Team leadership
- CRO management
Location
- South San Francisco, CA
Work Type
- On-site
- Full-time
Experience Level
- Associate Director
- Director
- 8+ years' experience
Education Level
- Ph.D. or equivalent in a related discipline (e.g. biochemistry, biophysics, analytical chemistry)
Salary/Compensations
- $165,000 - $250,000 annually
Benefits
- Medical Insurance
- Dental Insurance
- Vision Insurance
- Life Insurance
- Short Term Disability
- Long Term Disability
- Health Savings Account (HSA)
- Flexible Spending Accounts (FSA)
- 401k plan
- PTO
- Discretionary bonus
- Equity
About the Company
- TCG Labs-Soleil, established in partnership with The Column Group, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.
Equal Opportunity
- TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to contact@tcglsoleil.com.