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About the Role
As a Scientist in the Research Oncology team, you will be critical to delivering on the drug discovery pipeline by developing projects and designing experiments that yield key mechanistic insights to advance novel therapeutic targets and enable new drug discovery approaches. This position offers the opportunity to collaborate with cross-functional teams and utilize cutting-edge technologies to conduct highly impactful and creative research with the ultimate goal of improving patients’ lives.
Responsibilities
- Design, execute and interpret hypothesis-driven experiments to drive oncology drug discovery.
- Generate highly reproducible data and develop robust tools and assays.
- Engage in scientific discussion and stay up to date with the scientific literature.
- Propose new ideas or creative solutions and identify key experiments to validate therapeutic targets.
- Work productively with multidisciplinary teams across Genentech to support the validation and development of novel therapeutics.
- Foster a collaborative culture by sharing expertise and learning from others.
- Present and discuss data at regular lab meetings, team meetings, department forums, and cross-functional meetings.
Requirements
- Ph.D. in Molecular biology, Cancer Biology, or related fields, or M.Sc. with at least 3 years of research experience.
- Deep technical expertise in mammalian cell culture, including handling complex or difficult-to-culture models.
- Advanced cell engineering skills (CRISPR-Cas9 gene editing, lentiviral/transposon delivery, and generation of inducible or reporter cell lines).
- Hands-on mastery in executing cellular pharmacology and mechanistic assays (dose-response viability measurements, pathway modulation assays, Western blotting, qRT-PCR, and protein interaction/pull-down assays).
- Proven track record of rigorous, impactful research evidenced by peer-reviewed scientific publications, conference presentations, or documented milestone contributions within an industry drug discovery setting.
- High resilience, self-motivation, and scientific problem-solving capabilities.
- Exceptional collaboration skills in team-oriented settings.
Skills
- Mammalian cell culture
- Cell engineering
- CRISPR-Cas9 gene editing
- Lentiviral/transposon delivery
- Inducible or reporter cell line generation
- Cellular pharmacology assays
- Mechanistic assays
- Dose-response viability measurements
- Pathway modulation assays
- Western blotting
- qRT-PCR
- Protein interaction/pull-down assays
- Cancer signaling pathways
- Transcription factor biology
- Chromatin biology
- NGS experiment design and interpretation
- ATAC-seq
- ChIP-seq
- RNA-seq
- Advanced cellular imaging
- Live-cell microscopy
- High-content imaging
- Immunofluorescence (IF)
- Fluorescence in situ hybridization (FISH)
Location
- South San Francisco, CA
Work Type
- Full-time
Experience Level
- 3+ years of research experience (with M.Sc.)
Education Level
- Ph.D. in Molecular biology, Cancer Biology, or related fields
- M.Sc.
Salary/Compensations
- $103,400 to $192,000
- Discretionary annual bonus may be available
Benefits
- Relocation benefits are available
- Detailed benefits available at the provided link
About the Company
- Genentech is a research and development company focused on discovering and developing medicines to improve the lives of patients.
Equal Opportunity
- Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence.
- The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
- If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.