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About the Role
IDEAYA is a precision medicine oncology company focused on discovering, developing, and commercializing transformative cancer therapies. We are seeking an accomplished Senior Principal Research Scientist to make significant contributions to our Protein Sciences function, supervising and developing a team. This role is for an experienced scientist who excels at solving protein production challenges, supporting drug discovery programs, and coordinating scientific work.
Responsibilities
- Contribute actively in the laboratory while coordinating the day-to-day work and priorities of the Protein Sciences team.
- Develop and execute protein-expression and purification strategies for challenging proteins and protein complexes using bacterial, insect-cell, and other appropriate expression systems.
- Perform and oversee construct design, expression testing and optimization, protein purification, characterization, and troubleshooting.
- Ensure delivery of high-quality, fit-for-purpose protein reagents for biochemical, biophysical, structural, and screening applications.
- Partner closely with Bioassays, Biophysics, Structural Biology, Biology, Medicinal Chemistry, and Data Science to develop integrated experimental strategies.
- Supervise, mentor, and develop research associates and PhD-level scientists.
- Identify, engage, and coordinate CROs for protein expression, purification, characterization, and related activities.
- Communicate scientific strategies, findings, risks, and recommendations clearly to project teams and research leadership.
Requirements
- PhD with 9+ years’ hands-on expertise in recombinant protein production using bacterial and insect-cell expression systems.
- Demonstrated ability to independently develop and troubleshoot purification strategies for challenging proteins, protein complexes, and multiple construct variants.
- Hands-on experience with protein characterization methods such as SDS-PAGE, Western blotting, concentration determination, analytical SEC, thermal-stability methods, and assessment of aggregation and sample quality (i.e. SEC-MALS).
- Experience selecting and managing CROs or other external partners for protein production and characterization.
- Experience supervising and developing research associates and PhD-level laboratory scientists.
- Excellent oral, graphical, and written communication skills.
- Familiarity with global proteomics, phosphoproteomics, chemical biology, or chemoproteomics is desirable but not required.
- Experience with mammalian expression is desirable.
Skills
- Recombinant protein expression
- Protein purification
- Protein characterization
- Bacterial expression systems
- Insect-cell expression systems
- Mammalian expression systems
- SDS-PAGE
- Western blotting
- Analytical SEC
- Thermal-stability methods
- SEC-MALS
- CRO management
- Supervision
- Mentoring
- Scientific communication
Location
- South San Francisco, CA
Work Type
- Onsite (four days per week)
Experience Level
- Senior Principal
Education Level
- PhD
Salary/Compensations
- $180,000 - $223,000
Benefits
- Medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents)
- 401k
- ESPP
- Wellness programs
- Merit-based salary increases
- Company discretionary short-term incentive plan participation
- Company discretionary stock option awards
About the Company
- IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer.
- Our approach integrates expertise in small-molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first-in-class targeted therapies aligned to the genetic drivers of disease.
- We have built a deep pipeline of product candidates focused on synthetic lethality and antibody-drug conjugates, or ADCs, for molecularly defined solid tumor indications.
- Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer.
- We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA.
- We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.
Equal Opportunity
- The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law.
- IDEAYA is an equal opportunity employer.
- In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status.
- EOE/AA/Vets.
- We are committed to providing reasonable accommodations to qualified individuals with disabilities.