Impress employers and recruiters.
Choose from hundreds of resume examples.

Impress employers and recruiters.
Choose from hundreds of resume examples.

Target Resume Now

Tailor your resume to this Associate Scientist/Scientist I Protein Sciences (Cell Culture, Expression & Purification) role.

Rezi rewrites your resume against Soleil Labs, LLC's job description. Free.

Tailor your resume to this Associate Scientist/Scientist I Protein Sciences (Cell Culture, Expression & Purification) role.

Rezi rewrites your resume against Soleil Labs, LLC's job description. Free.

Tailor my resume

Don't guess if your resume is good enough.

See how it scores against the Associate Scientist/Scientist I Protein Sciences (Cell Culture, Expression & Purification) posting at Soleil Labs, LLC — free, in seconds.

Don't guess if your resume is good enough.

See how it scores against the Associate Scientist/Scientist I Protein Sciences (Cell Culture, Expression & Purification) posting at Soleil Labs, LLC — free, in seconds.

Get my score

About the Role

Join our innovative Protein Science team at TCG Labs-Soleil as a protein production expert! We are seeking a highly skilled, organized and motivated scientist to drive recombinant protein and antibody production across our expression and purification platforms. In this hands-on, pivotal role, you will independently design, execute, and optimize workflows spanning transient expression in HEK293 and CHO systems and high-throughput purification — delivering material across a broad range of molecule formats, from standard IgGs to complex multispecifics. You will work closely with colleagues across our expression, purification, and biology teams to interpret and communicate data, drive process improvement, advance our automation, and support our growing pipeline of protein and antibody-based therapeutics. The ideal candidate thrives in a fast-paced, collaborative environment, enjoys solving technical challenges, and brings strong hands-on expertise in mammalian cell culture and transient expression. This role is open at the Associate Scientist through Scientist I level. Title, scope, and independence will be calibrated to your experience.

Responsibilities

• Contribute and execute organization, traceability, and data integrity of high-throughput protein production workflows, including sample lineage, plate maps, inventory, experimental metadata, and results maintained in the ELN and internal databases.
• Independently design, execute, interpret, and troubleshoot cell culture, expression, and purification experiments; develop and optimize production strategies across platforms and scales.
• Drive transient expression platforms (HEK293 and CHO) from high-throughput (96-well) through medium-scale (1-5L) production to produce and purify a broad range of biologic formats including monoclonal IgGs, Fc-fusion proteins, and multispecific antibodies.
• Maintain and expand multiple mammalian cell lines and hosts (e.g., HEK293 variants, CHO lineages), suspension and adherent as needed, under rigorous aseptic technique.
• Support molecular biology efforts for protein expression, including construct design, gene synthesis coordination, cloning, plasmid preparation, and sequence verification.
• Execute high-throughput purification: semi-automated Kingfisher and automated, plate-based, and liquid-handler-driven purification.
• Integrate expression and purification with analytic techniques such as titer by Octet/BLI; purity and quality by SEC-HPLC, CE-SDS, SDS-PAGE).
• Author technical reports, protocols, and SOPs; present results and recommendations to cross-functional teams and leadership; contribute to program and platform strategy.

Requirements

• B.S. with 10+ years, M.S. with 6+ years, or Ph.D. with 0–2 years of relevant experience in Cell/Molecular Biology, Biochemistry, Bioengineering, or a related field.
• Strong hands-on expertise in mammalian cell culture and sterile/aseptic technique across multiple cell lines or hosts.
• Demonstrated experience with transient expression in HEK293 and CHO suspension systems.
• Experience producing and/or purifying multiple biologic molecule formats (e.g., IgGs, Fc-fusions); experience with multispecifics or other complex formats is advantageous.
• Experience with high-throughput protein production and workflows is desirable.
• Familiar with product-quality and titer analytics such as Octet/BLI and orthogonal methods.
• Working proficiency in molecular biology methods supporting expression (plasmid prep, PCR, cloning, DNA QC, Geneious).
• Informatics and data handling — Benchling ELN and plasmid/inventory management.
• Demonstrated ability to independently design experiments, interpret and present data, and drive projects to completion.
• Demonstrated ability to prioritize tasks and manage multiple projects in a dynamic, fast-paced environment.
• Strong team player with excellent organization, attention to detail, documentation practices, and cross-functional communication.
• General understanding of stable cell line development — pool and clone generation, single-cell cloning, selection, screening, and cell banking is a plus.
• Bioreactor experience — benchtop bioreactors and/or high-throughput micro-bioreactors (e.g., Ambr 15/250), fed-batch and/or perfusion, with process-parameter control and scale-up/scale-down modeling.
• High-throughput / automated purification — robotic Protein A, RoboColumns, plate-based clarification and purification — and liquid-handling platforms (Tecan, Hamilton, Beckman).

Skills

• Mammalian cell culture
• Transient expression
• HEK293 systems
• CHO systems
• Protein purification
• IgG production
• Fc-fusion protein production
• Multispecific antibody production
• Aseptic technique
• Molecular biology
• Construct design
• Gene synthesis coordination
• Cloning
• Plasmid preparation
• Sequence verification
• High-throughput purification
• Octet/BLI
• SEC-HPLC
• CE-SDS
• SDS-PAGE
• Benchling ELN
• Plasmid management
• Inventory management
• Stable cell line development
• Bioreactor operation
• Process parameter control
• Scale-up/scale-down modeling
• Robotic Protein A
• RoboColumns
• Plate-based clarification
• Liquid-handling platforms

Location

• South San Francisco

Work Type

• Full-time

Experience Level

• Associate Scientist
• Scientist I

Education Level

• B.S.
• M.S.
• Ph.D.

Salary/Compensations

• $91,000 - $140,000 annually

Benefits

• Medical Insurance
• Dental Insurance
• Vision Insurance
• Life Insurance
• Short Term Disability
• Long Term Disability
• Health Savings Account (HSA)
• Flexible Spending Accounts (FSA)
• 401k plan
• PTO

About the Company

• TCG Labs-Soleil, established in partnership with The Column Group, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

Equal Opportunity

• TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to contact@tcglsoleil.com.