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About the Role

As a Senior Laboratory Research Scientist within the GeMS team, you will play a key role in delivering, developing, and continuously improving specialist services that support the generation, archiving, and use of genetically altered animal models at the Crick. This is a hands-on scientific leadership role, combining practical laboratory work with responsibility for service development, project management, and the supervision and direction of colleagues.

Responsibilities

Perform practical work in genetic modification, cryopreservation, and rederivation of laboratory animals.
Contribute to and maintain laboratory records and databases.
Lead cryopreservation and rederivation activities, liaising with colony management services.
Oversee planning and delivery of cryopreservation and rederivation projects, monitoring performance and identifying bottlenecks.
Oversee the colony management of colonies undergoing cryopreservation and rederivation, assessing breeding performance and providing advice on strategies for complex lines.
Act as a technical expert in rodent assisted reproductive technologies, cryopreservation, and genetic manipulation techniques.
Troubleshoot complex technical and operational challenges, providing specialist support across the team.
Support scheduling, resource allocation, and day-to-day operational management of GeMS activities.
Assist in the oversight of GeMS projects and service delivery, ensuring work is completed to agreed timelines and quality standards.
Participate in strategic planning and service development across GeMS.
Promote awareness of all relevant health and safety guidance and legislation.
Ensure compliance to appropriate SOPs and risk assessments by all staff.
Order consumables via a computer ordering system, ensuring value for money and maintaining the budget.
Use Colony Management and cryo archive databases, maintaining accurate records for communication, reporting, and compliance.
Liaise effectively with all levels of Crick staff to ensure projects are completed in a timely and efficient manner.
Communicate effectively to foster and maintain good relationships and collaborations both internally and externally.

Requirements

A degree, or equivalent, in a biological subject, or related science or significant work experience in a relevant area.
Considerable relevant experience in Murine cryopreservation, ART, and genetic manipulation, including surgical experience, animal husbandry, colony management, project management, and scientific service provision with a track record of achievement and demonstrable skill.
Thorough understanding of the different genetically modified allele types, their limitations, and the breeding strategies appropriate for their use.
Proven track record in planning and successful execution of a scientific service or series of experiments to meet demands.
Evidence of successful troubleshooting of complex scientific tasks.
Experience of contributing effectively to the work of a team, demonstrating a flexible and cooperative approach to working with others.
Experience with working with animal models.

Skills

Genetic modification
Cryopreservation
Assisted reproductive techniques (ART)
Surgical experience
Animal husbandry
Colony management
Project management
Scientific service provision
Troubleshooting complex scientific tasks
Molecular biology
CRISPR-based targeting
Embryo micromanipulation and transfer
Assisted reproductive techniques
Cryopreservation
Rederivation of rodent and aquatic germplasm
Murine stem cell culture, maintenance, transfection, derivation and characterisation

Location

Onsite

Work Type

Full-time
Permanent
Limited opportunities for remote working

Experience Level

Senior

Education Level

Degree or equivalent in a biological subject, or related science

Salary/Compensations

From £47,080 with benefits, subject to skills and experience

Benefits

28 days of annual leave, plus three additional days over Christmas and bank holidays
Defined contribution pension with employer contributions of up to 16%
24/7 GP consultation services
Occupational health services and mental health support programs
Eye care vouchers and discounted healthcare plans
Back-up care for dependents
Childcare support allowance
Annual leave purchase options
Crick Networks offering diverse groups’ support, community and inclusive social events
Discounted gym memberships
Bike-to-work scheme
Shopping discounts
Subsidised on-site restaurant and social spaces

About the Company

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.
The Biological Research Facility (BRF) supports all animal research at the Crick through our comprehensive animal care and use program. The BRF provides the Crick's laboratory animal resource and technical services. High quality multidisciplinary in-vivo and ex-vivo research support are at the heart of the BRF's philosophy and operations. The BRF is committed to improving animal welfare, scientific quality, care of staff and transparency for stakeholders. The BRF teams integrate husbandry of multiple species within a range of facilities, using state of the art technologies, via a talented and skilled team.
Within the BRF, the Genetic Modification Services (GeMS) team provides specialist expertise in the production, storage and use of genetically modified animals and cell lines. The team delivers a broad range of services, including molecular biology and CRISPR-based targeting, embryo micromanipulation and transfer, assisted reproductive techniques, cryopreservation and rederivation of rodent and aquatic germplasm, and murine stem cell culture, maintenance, transfection, derivation and characterisation.

Equal Opportunity

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences.
We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: weronika.kucala@crick.ac.uk