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About the Role

Join Amgen's mission to serve patients by working at the intersection of disease biology, multi-omic profiling, computational analysis, and drug discovery to generate insights that advance therapeutic opportunities in respiratory, dermatologic, and/or rheumatologic diseases.

Responsibilities

• Develop and execute a disease-focused discovery strategy leveraging multi-omic and human data to deepen mechanistic understanding of respiratory, dermatologic, or rheumatologic diseases.
• Continuously adopt technology, AI/computation and innovation to improve efficiency and quality of work.
• Integrate systems immunology, multi-omics, AI-enabled biology, and human disease research to bring unique insights and innovative approaches to Amgen's discovery efforts.
• Lead cross-functional scientific initiatives that integrate human genetics, single-cell biology, spatial biology, proteomics, and computational analyses to identify and validate first/best-in-class therapeutic targets, patient segments and biomarker strategies.
• Drive generation and interpretation of multimodal datasets and translate findings into actionable hypotheses for target discovery and program prioritization/advancement.
• Partner closely with computational biology, translational sciences, human genetics, pathology, and disease-area biology teams to build integrated disease models and prioritize therapeutic opportunities.
• Serve as a scientific leader for disease-focused discovery efforts and provide expertise in human tissue biology, disease pathogenesis, and emerging technologies.
• Design and oversee internal and external collaborations with academic investigators, clinical researchers, consortia, and technology partners.
• Contribute to advancement of programs through target validation, indication selection, biomarker identification, and patient stratification strategies.
• Mentor scientists and foster rigorous, collaborative, and innovative scientific practices across project teams.
• Lead multiple cross-functional projects and scientific initiatives focused on disease understanding and target discovery.
• Influence the direction of several discovery programs through generation of disease insights and translational hypotheses.
• Serve as a recognized expert in disease biology and multi-omic analysis within the department.
• Contribute to departmental strategy related to human biology, disease understanding, and technology deployment.
• Build productive collaborations across research functions and external scientific communities.

Requirements

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and 4 years of relevant scientific experience
• Master’s degree and 7 years of relevant scientific experience
• Bachelor’s degree and 9 years of relevant scientific experience
• Significant experience in both academic research and biopharmaceutical drug discovery.
• Experience integrating human genetics, transcriptomics, proteomics, single-cell, spatial, imaging, and clinical datasets to generate actionable biological insights that inform target validation, biomarker strategies, patient stratification approaches, and drug discovery programs.
• Strong understanding of the drug discovery and development process, including target identification, validation, translational strategy, and preclinical development.
• Demonstrated ability to lead matrixed teams and build productive collaborations across scientific disciplines.
• Record of scientific achievement as evidenced by high-impact publications, presentations, patents, external collaborations, or contributions to advancing therapeutic programs.
• Curiosity-driven scientist with a passion for understanding human disease biology and leveraging emerging technologies to accelerate discovery.
• Excellent communication skills and ability to influence scientific strategy across diverse stakeholders.

Skills

• Human disease biology
• Multi-omic profiling
• Computational analysis
• Drug discovery
• Human genetics
• Transcriptomics
• Proteomics
• Spatial biology
• Single-cell technologies
• Systems immunology
• AI-enabled biology
• Pathology
• Biomarker strategies
• Patient stratification

Location

• US

Work Type

• Flexible work models where possible

Experience Level

• Associate Director
• 4 years of relevant scientific experience
• 7 years of relevant scientific experience
• 9 years of relevant scientific experience

Education Level

• Doctorate degree (PhD, PharmD, MD)
• Master’s degree
• Bachelor’s degree

Salary/Compensations

• 190,951.65USD -258,346.35 USD

Benefits

• Retirement and Savings Plan with generous company contributions
• Group medical, dental and vision coverage
• Life and disability insurance
• Flexible spending accounts
• Discretionary annual bonus program
• Stock-based long-term incentives
• Award-winning time-off plans

About the Company

• Amgen's mission is to serve patients living with serious illnesses.
• Pioneered the world of biotech in our fight against the world’s toughest diseases.
• Focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease.
• Advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.
• Award-winning culture is collaborative, innovative, and science based.
• Fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.

Equal Opportunity

• Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
• We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
• Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.