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About the Role
Amgen's Inflammation Research department is seeking a Senior Scientist for the In Vivo Pharmacology group to explore therapeutics for Inflammation, Autoimmune, and Rare Disease programs. This role involves designing and executing experiments, generating and communicating data, and providing technical expertise to support research projects and potentially manage a report.
Responsibilities
- Design, conduct and lead in vivo preclinical model studies and ex vivo analysis independently in collaboration with Inflammation scientists and collaborators.
- Design, execute and data analysis of cutting-edge research and in vivo pharmacology experiments contributing to Amgen’s Inflammation TA research pipeline.
- Utilize in vivo pharmacology and animal models to validate and accelerate molecules through the research pipeline.
- Inform, collaborate, and communicate in vivo planning and results with therapeutic area (TA) scientists to align with project goals.
Requirements
- PhD degree in immunology, biology, pharmacology or relative disciplines.
- Post-doc or industry experience will be a plus.
- Strong expertise in hands-on expertise in animal (rodent) handling and in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) essential.
- Significant experience designing and executing concurrent in vivo preclinical inflammation and autoimmune disease models. Experience with colitis, lupus, arthritis, immune modulation (TLR, DTH, Immunization), and respirotoray models preferred.
- Hands-on experience with ex vivo / in vitro cellular, and biochemical assay techniques (i.e. ELISA, MSD, WB, quantitative RT-PCR, tissue protein extraction) is essential.
- Significant experience with multicolor flow cytometry, including Spectral flow approaches and knowledge of and experience working with immune cell populations is essential.
- Experience working in a collaborative team-oriented environment and working on project teams leading in vivo contributions is essential.
- Attention to detail, excellent organizational, time management, and communication skills, accurate & timely record keeping and data analysis are essential.
- Demonstrated track record of independent critical thinking and scientific achievement.
- Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word.
- Doctorate degree OR Master’s degree in immunology or cell biology, or related discipline and 2 years of industry experience in biotech/pharma OR Bachelor’s degree in immunology or cell biology, or related discipline and 4 years of experience in biotech/pharma.
- Demonstrated track record of independent critical thinking and scientific achievement as exemplified by your publication record and / or significant contribution to a therapeutic program.
- Proactive, curious, and eager to learn and contribute to cutting edge science and serve patients in a highly productive team environment.
Skills
- in vivo techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy)
- preclinical inflammation and autoimmune disease models
- colitis
- lupus
- arthritis
- immune modulation (TLR, DTH, Immunization)
- respiratory models
- ex vivo / in vitro cellular, and biochemical assay techniques
- ELISA
- MSD
- WB
- quantitative RT-PCR
- tissue protein extraction
- multicolor flow cytometry
- Spectral flow approaches
- immune cell populations
- GraphPad Prism
- Excel
- PowerPoint
- Word
Location
- U.S. (excluding Puerto Rico)
Work Type
- Flexible work models where possible
Experience Level
- Senior Scientist
- Post-doc or industry experience
- 2 years of industry experience in biotech/pharma
- 4 years of experience in biotech/pharma
Education Level
- PhD degree in immunology, biology, pharmacology or relative disciplines
- Doctorate degree
- Master’s degree in immunology or cell biology, or related discipline
- Bachelor’s degree in immunology or cell biology, or related discipline
Salary/Compensations
- 123,052.80USD -166,483.20 USD
Benefits
- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
About the Company
- Join Amgen’s Mission of Serving Patients
- Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases.
- With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year.
- Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions.
- As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
- Our award-winning culture is collaborative, innovative, and science based.
- As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
- Together, we compete in the fight against serious disease.
Equal Opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
- Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
- Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.