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About the Role
Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.
Responsibilities
- Develop, optimize, validate, and standardize histopathology assays using FFPE samples, including single-plex and multiplex immunohistochemistry (IHC) and in situ hybridization (ISH) in colorimetric and immunofluorescent formats.
- Use imaging modalities and digital pathology tools to generate, analyze, and interpret tissue-based data for target qualification, pharmacodynamic and efficacy assessments, and biomarker development.
- Collaborate with pathologists, research investigators, and translational teams to deliver high-quality data supporting mechanism-of-action studies, in vivo model development, and toxicity assessments across therapeutic areas.
- Maintain clear, complete documentation and communicate results through laboratory information systems, databases, and team presentations.
Requirements
- Doctorate degree OR Master’s degree and 2+ years of relevant research and industry experience OR Bachelor’s degree and 4 years of relevant research and industry experience.
- PhD or master’s degree in cell biology, molecular biology, or related discipline.
- Two or more years of molecular pathology experience, preferably in an industry setting.
- Demonstrated expertise in pathology-based methods, including IHC, multiplex IHC, ISH and immunofluorescence imaging.
- Experience with digital pathology and image analysis, preferably using HALO and/or Visiopharm.
- Experience with automated staining platforms, such as Ventana, Leica Bond, or IntelliPATH, is preferred.
- Ability to manage multiple projects and priorities simultaneously.
- Excellent written and verbal communication skills.
- Experience analyzing pathology imaging data, including H&E, IHC, multiplex immunofluorescence, and/or spatial transcriptomics.
- Familiarity with whole-slide imaging and digital pathology platforms, such as HALO or Visiopharm, is preferred.
- Understanding of machine-learning methods for image segmentation, classification, detection, and representation learning.
- Strong communication, organizational, and collaboration skills in multidisciplinary scientific environments.
Skills
- Histopathology assays
- Multiplex assays
- Digital image analysis
- Target expression studies
- Preclinical model development
- Pharmacodynamics
- Biomarker discovery
- FFPE samples
- Immunohistochemistry (IHC)
- In situ hybridization (ISH)
- Colorimetric formats
- Immunofluorescent formats
- Imaging modalities
- Digital pathology tools
- Mechanism-of-action studies
- In vivo model development
- Toxicity assessments
- Laboratory information systems
- Databases
- Automated staining platforms
- HALO
- Visiopharm
- Machine-learning methods
- Image segmentation
- Image classification
- Detection
- Representation learning
Location
- South San Francisco, California
Work Type
- Onsite
Experience Level
- 2+ years of relevant research and industry experience
- 4 years of relevant research and industry experience
- Two or more years of molecular pathology experience
Education Level
- Doctorate degree
- Master’s degree
- Bachelor’s degree
Salary/Compensations
- 129,404.00USD -175,076.00 USD
Benefits
- Comprehensive employee benefits package
- Retirement and Savings Plan with generous company contributions
- Group medical, dental and vision coverage
- Life and disability insurance
- Flexible spending accounts
- Discretionary annual bonus program
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible
About the Company
- Amgen's mission is to serve patients living with serious illnesses.
- Since 1980, Amgen has pioneered the biotech industry in the fight against the world’s toughest diseases.
- Focuses on four therapeutic areas: Oncology, Inflammation, General Medicine, and Rare Disease.
- Advances a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions.
- The company has an award-winning culture that is collaborative, innovative, and science-based.
- Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Equal Opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- Amgen will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
- Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.