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About the Role
Xaira is seeking a motivated and detail-oriented Research Associate / Senior Research Associate for its Genomic Core team, focusing on next-generation sequencing (NGS). This role involves hands-on experience with Illumina sequencing, library preparation, single-cell workflows, and sequencer operation, contributing to cutting-edge genomics research and technology development.
Responsibilities
- Prepare high-quality sequencing libraries for Illumina platforms using a range of methods.
- Operate and maintain Illumina sequencers, including run setup, monitoring, troubleshooting, and basic maintenance.
- Support and execute single-cell workflows, including 10x Genomics GEM-X and 10x Flex assays.
- Perform QC of input material and libraries and assess data quality post-sequencing.
- Collaborate with internal teams to support project-specific NGS needs.
- Troubleshoot experimental issues independently and suggest improvements to protocols and workflows.
- Develop and optimize NGS protocols and contribute to the scaling of automated or high-throughput sequencing pipelines.
- Contribute to the development of scalable, high-throughput cloning and viral production pipelines.
- Maintain detailed electronic lab notebook (ELN) records and ensure rigorous documentation for reproducibility and compliance.
- Participate in group meetings and communicate experimental progress, challenges, and insights to broader teams.
- Run analysis pipelines (e.g., bcl2fastq, CellRanger).
Requirements
- B.S./M.S. in Molecular Biology, Genomics, Biotechnology, or a related field.
- 2+ years of laboratory experience, including direct experience in NGS workflows.
- Proficient in Illumina sequencing library preparation methods for DNA and RNA.
- Strong understanding of underlying biochemistry and assay design for library prep.
- Hands-on experience with Illumina sequencer operation and troubleshooting.
- Experience with quality control methods for nucleic acids and libraries.
- Strong organizational skills and meticulous attention to detail in both benchwork and data documentation.
- Comfortable working in a fast-paced, collaborative environment, supporting multiple projects and stakeholders.
Skills
- Illumina-based sequencing technologies
- Library preparation
- Single-cell workflows
- Sequencer operation
- TruSeq
- Nextera
- Amplicon
- MiSeq
- NextSeq
- NovaSeq
- 10x Genomics GEM-X
- 10x Genomics Flex assays
- Bioanalyzer
- TapeStation
- Qubit
- qPCR
- Library cloning techniques
- Vector design
- PCR
- Gibson assembly
- Golden Gate assembly
- Bacterial transformation
- Automated NGS library prep platforms
- Cloud-based LIMS
- Data tracking systems
- Benchling
- BaseSpace
- NGS data analysis
- Demultiplexing
- QC metrics interpretation
- Sequencing file formats
Location
- San Francisco Bay Area
- Seattle
- London
Work Type
- Full-time
Experience Level
- 2+ years of laboratory experience
- Research Associate
- Senior Research Associate
Education Level
- B.S./M.S. in Molecular Biology, Genomics, Biotechnology, or a related field
Salary/Compensations
- $90,000 - $115,000 annually
Benefits
- Competitive compensation and benefits package
- Open, flexible, and friendly work environment
- Platform to develop long-term careers
- Base salary
- Bonus
- Equity
About the Company
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
- It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
Equal Opportunity
- Xaira Therapeutics an equal-opportunity employer.
- We believe that our strength is in our differences.
- Our goal to build a diverse and inclusive team began on day one, and it will never end.