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About the Role

Translational Medicine is responsible for the early clinical development of novel therapeutics, working closely with Discovery Sciences and late-stage Clinical Research. This role focuses on Cardiovascular Disease and related conditions, requiring a strong background in basic and/or clinical translational research and a collaborative spirit.

Responsibilities

Leadership of early clinical development strategy for novel therapy programs from Preclinical Candidate approval through Clinical Pharmacology testing (Phase 1) and clinical Proof-of-Concept (Phase 2).
Development of biomarker strategies through cross-functional teams to provide line-of-sight from First-in-Human studies through clinical Proof-of-Concept, including Experimental Medicine studies.
Contribution to the identification of novel targets by partnering with discovery research teams to bring a clinical perspective into target identification and validation.
Execution of clinical studies to evaluate the relevance of potential targets to human disease.
Development and execution of clinical pharmacology strategies to support later stages of development from Proof-of-Concept (Phase 2) through worldwide marketing application.
Key member of an early development team, providing leadership in designing and executing early clinical development strategy.
Development and execution of early clinical strategy for novel therapeutics including authoring initial clinical and biomarker plans.
Development and execution of studies to validate clinical platforms utilizing established and novel biomarkers.
Provide clinical expertise for identification and validation of novel targets, including the design of preclinical and/or clinical pharmacology experiments.
Safe and timely execution of Phase I studies; close collaboration with internal and external clinical study support staff and scientists.
Provide clinical pharmacology support for programs through the worldwide marketing application filing.
Provide clear, timely communication and interpretation of study results to therapeutic area governance, functional area experts and development review committees.
Contribute to assessment of internal and external opportunities identified by Business Development and Licensing.
Interface broadly with key functions including Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations, Translational Medicine-EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late-stage Clinical Research.

Requirements

Proven track record in clinical medicine or clinical research, and background in biomedical research.
Demonstrated record of scientific scholarship and achievement including publications or presentations.
Strong interpersonal, writing and presentation skills.
Ability to function in a team environment.
Clinical Board Certification or Eligibility.
Subspeciality Clinical and Research experience in Cardiology or a related subspeciality (e.g. nephrology, pulmonary) is preferred but not required.
Prior experience in translational research and/or early clinical development preferred but not required.
Proven track record in clinical care of patient populations or management of clinical problem-solving.

Skills

Cardiology
Cardiovascular Medicine
Clinical Trials
Nephrology
Scientific Research
Translational Medicine
Translational Research

Location

US and Puerto Rico Residents Only

Work Type

Regular
Domestic Relocation
Hybrid

Experience Level

Principal Scientist
Clinical Director

Education Level

MD or MD/PhD

Salary/Compensations

$260,300.00 - $409,700.00

Benefits

Annual bonus and long-term incentive
Medical, dental, vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays, vacation, and compassionate and sick days

About the Company

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities.
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance