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About the Role

Translational Medicine is responsible for the early clinical development of novel therapeutics, working closely with Discovery Sciences and late-stage Clinical Research. This role focuses on Cardiovascular Disease and related conditions, requiring a strong background in basic and/or clinical translational research and a collaborative spirit.

Responsibilities

Lead the early clinical development strategy for novel therapy programs from Preclinical Candidate approval through Clinical Pharmacology testing (Phase 1) and clinical Proof-of-Concept (Phase 2).
Develop biomarker strategies through cross-functional teams to provide line-of-sight from First-in-Human studies through clinical Proof-of-Concept, including Experimental Medicine studies.
Contribute to the identification of novel targets by partnering with discovery research teams to bring a clinical perspective into early stages of target identification and validation.
Execute clinical studies to evaluate the relevance of potential targets to human disease to justify investment in clinical development programs.
Develop and execute clinical pharmacology strategies to support later stages of development from Proof-of-Concept (Phase 2) through worldwide marketing application.
Serve as a key member of an early development team, providing leadership in designing and executing early clinical development strategy.
Develop and execute early clinical strategy for novel therapeutics, including authoring initial clinical and biomarker plans.
Develop and execute studies to validate clinical platforms using established and novel biomarkers.
Provide clinical expertise for identification and validation of novel targets, including the design of preclinical and/or clinical pharmacology experiments.
Ensure safe and timely execution of Phase I studies, collaborating closely with internal and external clinical study support staff and scientists.
Provide clinical pharmacology support for programs through worldwide marketing application filing.
Communicate and interpret study results clearly and timely to therapeutic area governance, functional area experts, and development review committees.
Contribute to the assessment of internal and external opportunities identified by Business Development and Licensing.
Interface broadly with key functions including Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations, Translational Medicine-EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late-stage Clinical Research.

Requirements

MD or MD/PhD
Proven track record in clinical medicine or clinical research.
Background in biomedical research.
Demonstrated record of scientific scholarship and achievement including publications or presentations.
Strong interpersonal, writing, and presentation skills.
Ability to function in a team environment.
Clinical Board Certification or Eligibility (Preferred).
Subspeciality Clinical and Research experience in Cardiology or a related subspeciality (e.g., nephrology, pulmonary) is preferred but not required.
Prior experience in translational research and/or early clinical development preferred but not required.
Proven track record in clinical care of patient populations or management of clinical problem-solving.

Skills

Cardiology
Cardiovascular Medicine
Clinical Trials
Nephrology
Scientific Research
Translational Medicine
Translational Research

Location

Domestic

Work Type

Hybrid
Regular

Experience Level

Principal Scientist
Clinical Director

Education Level

MD
MD/PhD

Salary/Compensations

$260,300.00 - $409,700.00

Benefits

Medical, dental, vision healthcare and other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays, vacation, and compassionate and sick days

About the Company

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, is committed to inclusion and ensuring candidates can engage in a hiring process that exhibits their true capabilities.
We are proud to be a company that embraces the value of bringing together talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights
EEOC GINA Supplement
Learn more about your rights, including under California, Colorado and other US State Acts
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance