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About the Role
Regeneron is seeking a Cardiac and Vascular Rodent Surgeon to join our cardiovascular research team. This role is crucial for designing and executing in-vivo rodent studies to support cardiovascular disease programs. You will perform advanced surgical models, conduct precision dosing and monitoring, and generate data for therapeutic development.
Responsibilities
- Perform surgical models of cardiac and vascular disease in mice and rats, including TAC, MI, and RKM.
- Administer test articles via multiple routes (IV, SC, IM) or osmotic minipump implantation.
- Implant and manage telemetry devices for continuous blood pressure and ECG monitoring.
- Conduct invasive hemodynamic assessments using PV-loop methodology.
- Perform ex-vivo tissue collection and processing, including cardiac dissociation via Langendorff perfusion.
- Manage end-to-end in-vivo study logistics, including animal health monitoring, surgical scheduling, and post-operative care.
- Analyze and interpret physiological, hemodynamic, and functional data using PRISM, PONEMAH, and other relevant analysis software.
- Generate high-quality figures, reports, and data summaries for internal presentations, regulatory packages, and peer-reviewed publications.
- Maintain rigorous records of surgical procedures, animal welfare documentation, and study protocols.
- Collaborate closely with study directors, therapeutic area scientists, and cross-functional teams.
- Proactively flag capacity constraints, scheduling conflicts, or technical challenges to stakeholders.
Requirements
- BS with 10+ years or MS with 6+ years of relevant experience in a related field (e.g., Physiology, Biomedical Sciences, Veterinary Science, or similar).
- Demonstrated hands-on expertise in rodent cardiac and vascular surgical models (TAC, MI, RKM).
- Proficiency in rodent dosing techniques (IV, SC, IM) and telemetry implantation.
- Experience with invasive hemodynamic measurement techniques, including PV-loop analysis.
- Hands-on experience with Langendorff perfusion and cardiac tissue dissociation.
- Proficiency with data analysis software such as PRISM and PONEMAH.
- Strong understanding of rodent anatomy, physiology, and survival surgery best practices.
- Excellent organizational skills, with the ability to manage multiple longitudinal studies and competing priorities simultaneously.
- Strong attention to detail and commitment to scientific rigor and animal welfare standards.
- Excellent oral and written communication skills.
- Preferred: experience with additional cardiovascular functional assessment techniques or prior work in a GLP/regulated research environment.
Skills
- Rodent cardiac and vascular surgical models (TAC, MI, RKM)
- Rodent dosing techniques (IV, SC, IM)
- Telemetry implantation
- Invasive hemodynamic measurement techniques
- PV-loop analysis
- Langendorff perfusion
- Cardiac tissue dissociation
- PRISM
- PONEMAH
- Data analysis
- Scientific rigor
- Animal welfare standards
- Organizational skills
- Attention to detail
- Oral communication
- Written communication
Location
- Tarrytown, NY
Work Type
- Onsite
Experience Level
- 10+ years (BS)
- 6+ years (MS)
Education Level
- BS
- MS
Salary/Compensations
- $93,900.00 - $153,300.00
Benefits
- Annual bonuses or other incentive plans
- Equity awards
- Pension or retirement benefits
- 401(k) company match
- Health and wellness programs
- Fitness centers
- Insurance benefits (e.g. medical, dental, vision, life and disability)
- Paid time off
- Family support benefits
About the Company
- Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases.
- We are committed to building a workplace with an inclusive culture.
- We believe we do our best work when we are together.
Equal Opportunity
- Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.
- Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.