Senior/Staff RD System Integration Scientist - Electrochemical Enzymatic DNA Synthesis
Atlas Data Storage · CA, US
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About the Role
Serve as the cross-functional technical lead bridging chemistry, surface science, microfluidics, software automation, and CMOS hardware. Own the hands-on system integration of prototype testbeds, custom software scripts, and fluidic controls to reliably execute enzymatic DNA synthesis on chip. Drive platform performance from early-stage research integration through product-facing integration, process documentation, and technology transfer.
Responsibilities
- Contribute to the development, optimization, and system-level troubleshooting of CMOS chip-based enzymatic DNA synthesis workflows and electrochemical synthesis protocols.
- Drive the assay-to-instrument translation of complex enzymatic synthesis and electrochemical deblock onto automated CMOS chip-based synthesis platforms.
- Execute failure-mode analysis to identify, diagnose, and resolve root causes across hardware, fluidics, surface chemistry, and electrochemistry.
- Establish strategies to maximize enzymatic DNA synthesis workflow robustness, repeatability, and synthesis fidelity.
- Collaborate with hardware and software teams to improve and iterate prototype testbeds, integrating chemistry, fluidics, and hardware systems.
- Analyze complex experimental data using molecular biology, organic chemistry techniques, and automated scripting tools.
- Drive technology transfer from early-stage research integration to product-facing integration.
- Define and execute scientific and technical objectives aligned with company goals.
- Mentor junior research associates and engineers.
Requirements
- Advanced degree (Ph.D. or M.S.) in Electrochemical Engineering, Chemical Engineering, Biomedical Engineering, Fluidic Engineering, Chemistry, or a closely related discipline.
- Minimum 8 years of industry R&D experience for candidates holding a Master's degree or minimum 5 years of industry R&D experience for candidates holding a Doctoral degree.
- Demonstrated track record of leading assay-to-instrument translation through early research into product development.
- Extensive experience in system-level troubleshooting and failure-mode analysis across complex bio-instrumentation, fluidics, and bio-electronic interfaces.
- Proven capability in evaluating and optimizing biological workflow robustness for reproducible performance.
- Proven track record of leading multidisciplinary project teams or direct management and mentorship of junior scientists and research associates.
- Creative and detail-oriented personality with exceptional analytical, verbal, and written communication skills.
- Exceptional collaboration skills and ability to work seamlessly in a dynamic and fast-paced environment.
Skills
- Chemistry
- Surface Science
- Microfluidics
- Software Automation
- CMOS Hardware
- System Integration
- Enzymatic DNA Synthesis
- Electrochemical Synthesis
- Chip Handling
- Hardware Configuration
- Software Integration
- Assay-to-Instrument Translation
- Failure-Mode Analysis
- Workflow Robustness
- Repeatability
- Synthesis Fidelity
- Experimental Data Analysis
- Molecular Biology Techniques
- Organic Chemistry Techniques
- Automated Scripting Tools
- Technology Transfer
- Advanced Electrochemical Techniques (e.g., cyclic voltammetry, electrochemical impedance spectroscopy, ac voltammetry, chronoamperometry)
- Sensor Characterization on Solid Substrates
- Enzymatic DNA Synthesis Chemistries
- Oligonucleotide Microarray Platforms
- Single-Molecule Biosensing Instruments
- Python
- Software Scripting Tools for Instrument Automation
- Liquid Handling
- Hardware Control
- Pipeline Data Processing
Experience Level
- Minimum 8 years of industry R&D experience (Master's degree)
- Minimum 5 years of industry R&D experience (Doctoral degree)
Education Level
- Ph.D. or M.S. in Electrochemical Engineering, Chemical Engineering, Biomedical Engineering, Fluidic Engineering, Chemistry, or a closely related discipline.