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About the Role
Amgen is seeking a Director of Research to lead a portfolio of antibody-based therapeutics for solid tumors, implementing and advancing next-generation approaches for cancer therapeutics. This role offers high visibility and the opportunity to make a lasting impact on patients' lives.
Responsibilities
- Lead preclinical research for T cell engagers, focusing on identification of novel target opportunities, prioritization of discovery investments, and implementation of next-generation target discovery approaches.
- Build and lead a portfolio of innovative research programs focused on bispecific antibodies.
- Lead a team of project leaders and lab-based scientists to create an inclusive, high-performing environment that enables new target discovery, rigorous science, and efficient execution.
- Lead cross-functional teams and engage key internal partners to integrate tumor biology, target validation, translational research, therapeutic modality considerations, and portfolio strategy.
- Establish productive external scientific collaborations and contribute to the evaluation of external opportunities, including business development diligence.
- Partner effectively with peers across research and development to advance new science and integrate technology with tumor cell biology, including the application of AI/ML approaches to target and biology evaluation.
Requirements
- Doctorate degree in Cancer Biology, Cell Biology, Genetics, or related field and 4 years of directly related experience OR Master’s degree in Cancer Biology, Cell Biology, Genetics, or related field and 8 years of directly related experience OR Bachelor’s degree in Cancer Biology, Cell Biology, Genetics, or related field and 10 years of directly related experience.
- At least 4 years of experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation of resources.
- Doctoral degree in a Cancer Biology, Cell Biology or related field with at least 12 years industry experience following completion of postdoctoral training.
- Demonstrated experience leading drug discovery and development programs through IND/CTA-enabling activities, with strong experience in large-molecule therapeutics and understanding of the preclinical data sets required for development candidate nomination.
- Deep understanding of oncology and tumor biology; expertise in NSCLC or lung cancer biology is strongly preferred.
- Knowledge of antibody engineering approaches, with direct experience designing and evaluating modalities including T-cell engagers and antibody-drug conjugates.
- Established record of building, mentoring, and leading high-performing research teams.
- Exceptional written and verbal communication skills, with the ability to synthesize complex data into clear strategic recommendations.
- Demonstrated scientific impact through publications, patents, invited presentations, or other external recognition.
- Demonstrated ability to use AI/ML to accelerate research and translational biology.
Skills
- T-cell engager programs
- Translational biology
- Cancer cell biology
- Human genetics
- Cell growth signaling pathways
- Mechanisms of response and resistance
- Translational pharmacology
- Antibody engineering
- AI/ML
Location
- US
Work Type
- Onsite
Experience Level
- Director
- 4 years of directly related experience
- 8 years of directly related experience
- 10 years of directly related experience
- 12 years industry experience
Education Level
- Doctorate degree
- Master’s degree
- Bachelor’s degree
Salary/Compensations
- 208,353.70 USD - 281,890.30 USD
Benefits
- Comprehensive employee benefits package
- Retirement and Savings Plan with generous company contributions
- Group medical, dental and vision coverage
- Life and disability insurance
- Flexible spending accounts
- Discretionary annual bonus program
- Stock-based long-term incentives
- Award-winning time-off plans
About the Company
- Amgen is a leader in the discovery and development of innovative cancer therapeutics.
- Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.
- Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients.
Equal Opportunity
- Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
- We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
- Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.