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About the Role
The Senior Scientist will join the Respiratory Biology Discovery group to contribute to target identification, validation, translational biology, and mechanism-of-action studies for early discovery programs in chronic lung diseases. The role emphasizes leveraging human-relevant experimental systems, particularly primary airway and alveolar epithelial biology, and generating high-quality mechanistic datasets to inform target prioritization and program decisions.
Responsibilities
- Design, execute, and interpret in vitro and ex vivo studies to support respiratory target discovery, validation and translational biology programs.
- Develop and apply disease‑relevant experimental systems, including primary airway epithelial cultures, air‑liquid interface (ALI) models, organoid systems, precision-cut lung slices (PCLS), and co-culture platforms.
- Generate mechanistic datasets to investigate epithelial dysfunction, tissue remodeling, fibrosis, immune responses, and regenerative biology in chronic lung diseases.
- Apply imaging techniques, including immunohistochemistry (IHC), immunofluorescence (IF), and high‑content imaging, with image‑based analysis to interrogate disease-relevant biology.
- Perform and interpret flow cytometry/FACS‑based immune and cell phenotyping.
- Support translational biomarker discovery and validation using patient-derived samples and multiplex biomarker platforms (Meso Scale Discovery, Luminex, Olink, AlphaLISA).
- Integrate cellular, molecular, imaging, and biomarker datasets to inform project decisions and translational strategies.
- Generate reproducible, high-quality data packages and communicate findings through presentations, technical reports, and cross-functional discussions.
- Collaborate closely across biology, pharmacology, DMPK, and translational and clinical teams within a matrixed discovery environment.
Requirements
- Demonstrated expertise in respiratory biology and human primary cell culture systems, including airway and/or alveolar epithelial models
- Experience developing and applying disease-relevant in vitro and ex vivo systems such as ALI cultures, organoids, co-culture models, or precision-cut lung slices
- Strong hands-on experience in molecular and cellular biology techniques
- Experience with flow cytometry/FACS, imaging-based approaches (IHC, IF, ICC, confocal microscopy), image analysis, and multiplex biomarker platforms (Meso Scale Discovery, Luminex, Olink, AlphaLISA or equivalent)
- Experience supporting translational biology, target validation, and mechanism-of-action studies
- Ability to independently design, execute, troubleshoot, and interpret experimental studies
- Strong scientific communication skills and ability to present findings in cross-functional settings
- Prior experience in respiratory drug discovery, fibrosis, tissue remodeling, regenerative biology, or inflammatory lung disease research
- Experience with macrophage, fibroblast, epithelial, or immune-stromal co-culture systems
- Experience working with patient-derived respiratory tissues and primary human lung cells
- Familiarity with transcriptomic datasets including bulk RNA-seq and single-cell RNA-seq
- Experience with organoid biology, human tissue-based models, or spatial biology approaches
- Knowledge of translational biomarker strategies and human disease-relevant endpoints
Skills
- Cell Biology
- Cell Culture Techniques
- Image Analysis
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Luminex Assays
- Meso Scale Discovery
- Molecular Techniques
- Pulmonary Disease Research
- Target Validation
Location
- Domestic/International
Work Type
- Regular
- 10% Travel
Experience Level
- 7+ years (Bachelor's)
- 4+ years (Master's)
- Ph.D.
Education Level
- Bachelor's degree in biology, immunology, pharmacology, physiology, pulmonary biology or related discipline
- Master's degree in biology, immunology, pharmacology, physiology, pulmonary biology or related discipline
- Ph.D. in biology, immunology, pharmacology, physiology, pulmonary biology or related discipline
Salary/Compensations
- $131,400.00 - $206,800.00
Benefits
- Annual bonus and long-term incentive, if applicable
- Medical, dental, vision healthcare and other insurance benefits (for employee and family)
- Retirement benefits, including 401(k)
- Paid holidays, vacation, and compassionate and sick days
About the Company
- Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA
- We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Equal Opportunity
- As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
- Learn more about your rights, including under California, Colorado and other US State Acts
- San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
- Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance