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About the Role
Xaira Therapeutics is seeking a Scientist II to spearhead the design and execution of experiments using functional genomics and synthetic biology approaches to accelerate drug discovery and development. This role involves developing high-throughput screens, driving new technology initiatives, and contributing to a collaborative, cross-functional team.
Responsibilities
- Design, implement, and optimize biochemical, molecular and cell-based assays to support high throughput screening platform development.
- Scale high-throughput screening strategies for binder discovery in mammalian systems.
- Evaluate and pilot emerging technologies and experimental workflows to enhance discovery capabilities.
- Develop and optimize automated workflows, ensuring data quality, reproducibility, and process efficiency.
- Partner with drug discovery, computational biology, and AI-based protein design teams to analyze, interpret, and share insights from screening data.
- Independently manage multiple projects, ensuring timely delivery of high-quality data and adherence to team goals.
- Maintain accurate records of experiments, protocols, and findings, and contribute to internal and external scientific presentations.
Requirements
- Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics, or related field, with 2-4 years of postdoctoral or industry experience.
- Proficiency with molecular biology techniques, complex library construction, flow cytometry and cell line engineering.
- Experience with pooled screening and NGS-based readouts, including library preparation and sequencing QC.
- Strong analytical skills and the ability to troubleshoot complex experimental issues independently.
- Strong data analysis capabilities, including proficiency with visualization and statistical software (e.g., GraphPad Prism, R, Python).
- Excellent written and verbal communication skills; ability to present scientific findings clearly and concisely to diverse audiences.
- Enthusiastic team player who can work effectively across interdisciplinary teams and drive cross-functional projects.
Skills
- Functional genomics
- Synthetic biology
- High-throughput screening
- Molecular biology techniques
- Complex library construction
- Flow cytometry
- Cell line engineering
- Pooled screening
- NGS-based readouts
- Library preparation
- Sequencing QC
- Data analysis
- GraphPad Prism
- R
- Python
Location
- San Francisco Bay Area
- Seattle
- London
Work Type
- Full-time
Experience Level
- Scientist II
- 2-4 years of postdoctoral or industry experience
Education Level
- Ph.D.
Salary/Compensations
- $124,000 to $155,000 annually
Benefits
- Competitive compensation and benefits package
- Open, flexible, and friendly work environment
- Platform to develop long-term careers
- Base salary
- Bonus
- Equity
About the Company
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
- It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
Equal Opportunity
- Xaira Therapeutics an equal-opportunity employer.
- We believe that our strength is in our differences.
- Our goal to build a diverse and inclusive team began on day one, and it will never end.