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About the Role

Shape the chemical foundation of Bayer's R&D pipeline for new chemical entities by designing, developing, and enabling synthetic routes that evolve into robust API manufacturing processes in partnership with external CDMOs. This role defines and drives the Drug Substance (DS) strategy and is accountable for the DS contribution to the overall CMC package, acting as the central interface between internal stakeholders and external partners.

Responsibilities

Provide scientific leadership for the design, assessment, and optimization of synthetic routes for new APIs in preclinical and clinical phases, focusing on speed, quality, cost, sustainability, and process understanding.
Represent Drug Substance (DS) in global CMC development project teams and contribute to key scientific, strategic, and portfolio decisions.
Ensure a coherent two-way flow of strategy, decisions, risks, and progress between the internal global CMC team and external CDMO activities.
Guide and challenge route design and synthetic methodology choices at external CDMOs, translating SAR-driven chemistry into scalable routes for preclinical and clinical supply and future production.
Oversee external API campaigns for toxicology studies and clinical trials, including planning, risk assessment, supply-demand alignment, and budget oversight.
Steer process transfers between external partners and into internal development or external manufacturing, ensuring knowledge continuity and phase-appropriate documentation.
Contribute to robust, phase-appropriate control strategies.
Co-author and review the Drug Substance sections of regulatory filings (IND/IMPD and briefing documents) and support responses to health authority questions.
Provide CMC DS assessments for in-licensing opportunities.
Provide chemical expertise and pragmatic troubleshooting across the internal and external manufacturing network.
Actively contribute to the chemistry community by sharing knowledge and driving innovation across organizational boundaries.

Requirements

Ph.D. in Chemistry or a related science.
Extensive experience in the pharmaceutical industry, including an understanding of GLP/GMP and regulatory expectations.
Strong background in synthetic chemistry, with an excellent understanding of reagents, methodologies, and reaction mechanisms.
Solid grasp of analytical techniques.
Experience in steering external partners (CROs/CDMOs) or working across an external manufacturing network is a clear advantage.
Proven ability to represent chemistry and Drug Substance in interdisciplinary CMC or project teams.
Ability to act as an accountable interface between the internal organization and external partners.
A strategic thinker with the ability to think innovatively, develop and analyze multiple solutions to complex chemistry problems, and challenge the status quo.
Strong communication and project management skills across scientific disciplines, cultures, and organizational boundaries.
Assertiveness, service orientation, and enjoyment of cross-functional teamwork.
Fluency in English (negotiation level), both written and spoken.
Willingness to learn German is required.

Skills

Synthetic chemistry
Process chemistry
API manufacturing
Chemical process development
API supply
Scalable manufacturing
Sustainable manufacturing
Process understanding
Route design
Synthetic methodology
Analytical techniques
Project management
Cross-functional teamwork

Location

Germany: North Rhine Westfalia: Wuppertal-Elberfeld
Germany: Berlin: Berlin

Work Type

Full-time

Experience Level

Senior Principal Scientist

Education Level

Ph.D. in Chemistry or a related science

Salary/Compensations

109.800€ - 138.500€ per year

Benefits

Competitive salary plus a variable component and a global equity-based cash plan.
Flexible, appreciative, and tailored benefits package.
Loving company daycare centers at multiple locations.
Support in finding childcare.
Time off for the care of elderly or dependent family members.
Summer camps for children.
Access to learning and development opportunities.
Training programs through the Bayer Learning Academy.
Development dialogues.
Coaching and mentoring programs.
Health awareness and opportunities for selfcare.
Free health checks with the company doctor.
Inclusive work environment.

About the Company

At Bayer, we are visionaries, driven to solve the world's toughest challenges and striving for a world where 'Health for all, Hunger for none' is a reality.
We are doing it with energy, curiosity and sheer dedication, always learning from unique perspectives of those around us, expanding our thinking, growing our capabilities and redefining ‘impossible’.
Our success begins with you. Be part of something big. Be Bayer.

Equal Opportunity

Bayer welcomes applications from all individuals, regardless of race, national origin, gender, age, physical characteristics, social origin, disability, union membership, religion, family status, pregnancy, sexual orientation, gender identity, gender expression or any unlawful criterion under applicable law.
We are committed to treating all applicants fairly and avoiding discrimination.