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About the Role
The VP, Product Team Leader (PTL) is accountable for the integrated strategy, decision process, and execution of assigned pipeline assets, guiding programs from development candidate through clinical proof of concept. This role translates scientific, clinical, and commercial opportunities into a differentiated global product strategy and an execution-ready Integrated Development Plan, aligning scope, timelines, investment, and evidence generation with corporate priorities.
Responsibilities
- Define the asset vision, target product profile, and value proposition by integrating patient need, scientific rationale, competitive landscape, regulatory opportunity, access, and commercial potential.
- Lead indication prioritization, development scenarios, and investment choices, establishing a clear path to proof of concept with an initial view toward registration, commercialization, and lifecycle management.
- Adapt strategy as the scientific, clinical, regulatory, and market landscape evolves while preserving optionality and asset value.
- Chair a Product Team of empowered leaders across relevant research, development, medical, operational, commercial, legal, and finance functions.
- Build an inclusive, high-accountability team culture that supports rigorous debate, transparent communication, timely execution, and collective ownership of program outcomes.
- Clarify decision rights and escalation pathways, leading integrated decisions with clear owners, criteria, options, tradeoffs, timing, and execution plans.
- Lead program risk management, scenario planning, contingencies, and escalation of material changes to the appropriate governance forum.
- Partner with the Chief Medical Officer, Clinical Development leadership, and the Clinical Development Lead to ensure clinical plans are scientifically rigorous, medically appropriate, feasible, and differentiated.
- Guide protocol strategy, cohort and indication sequencing, proof-of-concept criteria, dose and regimen decisions, biomarker strategy, data-readout planning, and interpretation of emerging evidence.
- Ensure cross-functional readiness for key milestones, including IND/CTA, first patient dosed, cohort expansion, recommended Phase 2 dose, proof of concept, later-stage development, filing, and launch, as applicable.
- Participate in key health authority interactions and maintain alignment among regulatory strategy, clinical evidence, CMC readiness, and commercial objectives.
- Partner with Program Management to maintain the integrated plan, critical path, decision calendar, risk register, governance cadence, and readiness packages.
- Develop and defend program budgets and resource requirements, evaluate time-cost-risk tradeoffs, and ensure execution within approved scope and investment.
- Identify cross-program dependencies and constraints, resolve conflicts with functional and portfolio leaders, and recommend enterprise-level tradeoffs.
- Drive operational excellence, quality, inspection readiness, and compliance with applicable global requirements.
Requirements
- Advanced degree (Ph.D., M.D., Pharm.D., or equivalent) strongly preferred.
- 15+ years of progressive pharmaceutical or biotechnology experience, with substantial leadership of complex development programs.
- Demonstrated drug-development leadership, including expertise in tumor biology, translational strategy, and the competitive landscape.
- Proven success executing global development strategies from early development through proof of concept and participating in major health authority interactions.
- Exceptional executive communication and business acumen, with the ability to navigate ambiguity and present clear recommendations to senior leadership.
Skills
- Tumor biology
- Translational strategy
- Competitive landscape analysis
- Global development strategies
- Executive communication
- Business acumen
- Navigating ambiguity
Location
- San Diego
Work Type
- Full-time
Experience Level
- 15+ years of progressive pharmaceutical or biotechnology experience
- Substantial leadership of complex development programs
Education Level
- Advanced degree (Ph.D., M.D., Pharm.D., or equivalent) strongly preferred
Salary/Compensations
- $275,000 to $320,000
Benefits
- Target bonus
- Long-term-incentives
- 401k retirement savings plan with company match
- Comprehensive benefits package including medical, dental, vision, life, and disability insurance
About the Company
- Vividion is a next generation biotechnology company based in San Diego leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions.
- Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”.
- Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action against undruggable targets in the oncology and immunology space.
- We prize scientific excellence, creativity, team players and are committed to continued innovation.
- We have created a collaborative and dynamic work culture where ideas and discoveries are valued and will have an impact.
- Opportunities for mentorship and career progression are available.
- Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.
Equal Opportunity
- Vividion Therapeutics, Inc. is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other characteristic protected by applicable federal, state, or local laws.