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About the Role
This position supports the company’s biologics drug discovery and development efforts within the DMPK Group. The role involves generating in vitro and in vivo ADME and pharmacokinetic data to support biologics programs, applying expertise in protein biochemistry and biophysics to understand molecular properties influencing clearance mechanisms and PK/PD relationships of various biologics modalities. The scientist will work closely with project teams and partner groups to advance drug discovery efforts.
Responsibilities
- Perform routine and exploratory biochemistry and biophysics-based assays, including protein biochemistry and biophysical interaction assays to quantify receptor binding, cellular trafficking and degradation, non-specific binding/clearance and other DMPK properties of biologics.
- Partner with cross-functional teams to design, optimize, and execute assays aligned with project needs.
- Generate and analyze data with high attention to detail, and maintain complete and accurate electronic laboratory notebooks.
- Contribute to the implementation of automation solutions and semi-automated workflows to increase throughput and reproducibility.
- Support the development and optimization of protocols and standard operating procedures and maintain and troubleshoot instruments.
- Communicate experimental plans and results clearly via written reports and verbal presentations.
Requirements
- Bachelor’s (with 3+ years) or Master's in biochemistry, biophysics, biotechnology, bioengineering, pharmacology or a related scientific discipline and relevant laboratory experience.
- Strong foundation in protein biophysics/biochemistry principles, with the ability to apply these concepts in a biological or translational context (e.g., protein interactions, binding kinetics, intracellular trafficking, in vivo clearance).
- Hands-on experience with biochemical/biophysical techniques to characterize proteins (e.g., immunoprecipitation, flow cytometry, mass spectrometry, SPR/BLI, meso scale discovery, fluorescence spectroscopy, NMR/ HDX/MS).
- Ability to analyze, troubleshoot, organize, and interpret data, with familiarity using software such as GraphPad Prism, Excel, or similar tools.
- Excellent attention to detail, strong documentation practices, and the ability to work in a fast-paced research environment.
- Strong interpersonal, problem-solving, and communication skills with a collaborative and growth-oriented mindset.
- Experience with biologics DMPK assays, such as receptor binding kinetics, drug/receptor internalization, and cellular trafficking assays.
- Experience in cell culture and execution of cell‑based functional assays.
- Experience quantifying protein concentrations in biological matrices using ligand-binding assays (e.g., ELISA, meso scale discovery, etc.).
- Prior experience with Octet/BLI, SPR, or similar biophysical techniques.
- Exposure to automation, liquid handlers, or high-throughput assay systems.
Skills
- Biochemistry
- Biophysics
- Flow Cytometry
- Fluorescence Spectrometer
- Intracellular Trafficking
- Kinetic Studies
- Mass Spectrometry (MS)
- Molecular Biophysics
- Protein Interactions
- Protein biochemistry
- Protein biophysics
- GraphPad Prism
- Excel
Location
- South San Francisco
Work Type
- Regular
- Domestic Relocation
- 1st - Day Shift
Experience Level
- 3+ years relevant laboratory experience
Education Level
- Bachelor's Degree
- Master's Degree
Salary/Compensations
- $108,000.00 - $170,100.00
Benefits
- Annual bonus and long-term incentive, if applicable.
- Medical, dental, vision healthcare and other insurance benefits (for employee and family).
- Retirement benefits, including 401(k).
- Paid holidays, vacation, and compassionate and sick days.
About the Company
- Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA.
- Committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities.
- Embraces the value of bringing together talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
- Encourages colleagues to respectfully challenge one another’s thinking and approach problems collectively.
Equal Opportunity
- As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
- As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
- San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
- Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.