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About the Role

This position supports the Company’s biologics drug discovery and development efforts within the DMPK Group at the R&D Division in South San Francisco. The role involves generating in vitro and in vivo ADME and pharmacokinetic data to support biologics programs, applying expertise in protein biochemistry and biophysics to understand molecular properties influencing clearance mechanisms and PK/PD relationships of various biologics.

Responsibilities

Perform routine and exploratory biochemistry and biophysics-based assays, including protein biochemistry and biophysical interaction assays to quantify receptor binding, cellular trafficking and degradation, non-specific binding/clearance and other DMPK properties of biologics.
Partner with cross-functional teams to design, optimize, and execute assays aligned with project needs.
Generate and analyze data with high attention to detail, and maintain complete and accurate electronic laboratory notebooks.
Contribute to the implementation of automation solutions and semi-automated workflows to increase throughput and reproducibility.
Support the development and optimization of protocols and standard operating procedures and maintain and troubleshoot instruments.
Communicate experimental plans and results clearly via written reports and verbal presentations.

Requirements

Bachelor’s (with 3+ years) or Master's in biochemistry, biophysics, biotechnology, bioengineering, pharmacology or a related scientific discipline and relevant laboratory experience.
Strong foundation in protein biophysics/biochemistry principles, with the ability to apply these concepts in a biological or translational context (e.g., protein interactions, binding kinetics, intracellular trafficking, in vivo clearance).
Hands-on experience with biochemical/biophysical techniques to characterize proteins (e.g., immunoprecipitation, flow cytometry, mass spectrometry, SPR/BLI, meso scale discovery, fluorescence spectroscopy, NMR/ HDX/MS).
Ability to analyze, troubleshoot, organize, and interpret data, with familiarity using software such as GraphPad Prism, Excel, or similar tools.
Excellent attention to detail, strong documentation practices, and the ability to work in a fast-paced research environment.
Strong interpersonal, problem-solving, and communication skills with a collaborative and growth-oriented mindset.
Experience with biologics DMPK assays, such as receptor binding kinetics, drug/receptor internalization, and cellular trafficking assays.
Experience in cell culture and execution of cell-based functional assays.
Experience quantifying protein concentrations in biological matrices using ligand-binding assays (e.g., ELISA, meso scale discovery, etc.).
Prior experience with Octet/BLI, SPR, or similar biophysical techniques.
Exposure to automation, liquid handlers, or high-throughput assay systems.

Skills

Biochemistry
Biophysics
Flow Cytometry
Fluorescence Spectrometer
Intracellular Trafficking
Kinetic Studies
Mass Spectrometry (MS)
Molecular Biophysics
Protein Interactions
Protein biochemistry
Protein biophysics
Receptor binding
Cellular trafficking
Non-specific binding/clearance
PK/PD relationships
GraphPad Prism
Excel
Ligand-binding assays
ELISA
Meso scale discovery
Octet/BLI
SPR
Automation
Liquid handlers
High-throughput assay systems

Location

South San Francisco

Work Type

Onsite
Regular
1st - Day shift

Experience Level

3+ years relevant laboratory experience

Education Level

Bachelor's degree
Master's degree

Salary/Compensations

$108,000.00 - $170,100.00

Benefits

Annual bonus
Long-term incentive
Medical, dental, vision healthcare
Other insurance benefits (for employee and family)
Retirement benefits, including 401(k)
Paid holidays
Vacation
Compassionate and sick days

About the Company

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities.
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds.
The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment.
We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Equal Opportunity

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.
As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance.
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance.