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About the Role

Lead the strategy, operations, security, and evolution of Maze’s enterprise technology environment. This role requires balancing strategy with hands-on execution, leading the internal IT team, and evolving the operating model with Managed Service Providers (MSPs) and strategic partners to deliver reliable, secure, and responsive technology services. Ensure the technology environment can scale with the business as Maze advances its clinical programs and prepares for global development. Partner across functions to modernize work, strengthen cybersecurity, improve employee technology experience, and expand AI and automation.

Responsibilities

Develop and execute Maze’s enterprise IT strategy and roadmap aligned with business growth, clinical development, security, and compliance needs.
Lead the delivery of enterprise IT services, including Microsoft 365, identity and access management, endpoints, networking, cloud services, business applications, and end-user support.
Modernize the employee technology experience, including onboarding, access provisioning, support, and authentication.
Establish meaningful service levels, operational metrics, and performance expectations that drive accountability and continuous improvement.
Own IT financial planning and investment prioritization, balancing business value, risk, employee experience, scalability, and cost.
Lead Maze’s transition to an effective MSP-enabled operating model across end-user support and infrastructure.
Establish clear roles, accountability, service expectations, and ways of working between internal IT leaders, MSPs, and strategic technology partners.
Lead, coach, and develop Maze’s IT leadership team, building trust, collaboration, and shared accountability across IT Operations, Infrastructure, and Helpdesk.
Manage vendor performance, service quality, escalation, cost, and continuous improvement while ensuring Maze retains ownership of technology strategy, security, risk, and business outcomes.
Create a service-oriented culture where internal teams and external partners operate as one IT organization focused on delivering an exceptional employee experience.
Remain close enough to the technology and operations to identify issues, remove roadblocks, and guide the team effectively.
Develop and execute Maze’s cybersecurity strategy and multi-year roadmap, maturing capabilities across identity, endpoints, networks, SaaS applications, data protection, monitoring, third-party risk, and incident response.
Improve Maze’s ability to proactively identify, assess, and mitigate cybersecurity risks.
Maintain strong disaster recovery, business continuity, and incident response capabilities.
Support SOX, GDPR, audits, access controls, and applicable GxP and computer system validation requirements.
Build trusted partnerships across Clinical Development, Quality, Regulatory, Finance, Legal, HR, Research, Drug Discovery, and Technical Operations.
Establish a proactive IT business-partnership model that anticipates functional needs, identifies opportunities to improve how teams work, and translates those needs into the technology roadmap.
Support the technology needs of global clinical development and external partners, including CROs and other service providers.
Partner with business owners on the selection and implementation of critical platforms, including clinical, quality, and document-management systems.
Translate business needs into practical, scalable technology solutions.
Help lead the continued evolution of AI@Maze, enabling secure and responsible use of enterprise AI.
Partner with Informatics, Data Science, Legal, and business teams on AI governance, architecture, security, and adoption.
Evaluate enterprise AI platforms and opportunities to connect approved AI tools with internal Maze information such as SharePoint.
Identify opportunities to automate routine work and improve productivity across the company.

Requirements

15+ years of progressive IT experience, including 5+ years in technology leadership.
Experience in biotechnology, pharmaceutical, life sciences, or another highly regulated environment; clinical-stage and public-company experience strongly preferred.
Demonstrated success leading enterprise IT in a cloud-first, SaaS-based environment.
Experience managing MSPs and strategic technology partners.
Strong cybersecurity, business continuity, disaster recovery, and compliance experience.
Familiarity with SOX, GDPR, GxP, GAMP 5, and computer system validation.
Experience supporting enterprise applications, identity and access management, endpoint management, networking, and end-user services.
Experience improving operations through automation and emerging technologies, including AI.
Strong business judgment, communication skills, and ability to partner effectively with senior leaders and cross-functional teams.
Demonstrated ability to lead through change while remaining hands-on when needed.
You’re a technology leader who enjoys building strong teams, improving operations, and solving business problems.
You can move comfortably between strategy and execution, know how to get the best from MSPs without outsourcing accountability, and believe IT should be a trusted partner that makes the company more secure, productive, and effective.
You bring curiosity about emerging technologies and AI, balanced with strong judgment around security, privacy, compliance, and business value.

Skills

Microsoft 365
Identity and access management
Endpoint management
Networking
Cloud services
Business applications
End-user support
Cybersecurity strategy
Disaster recovery
Business continuity
Incident response
SOX
GDPR
GxP
Computer system validation
AI
Automation

Location

South San Francisco

Work Type

Hybrid

Experience Level

Senior Director
15+ years of progressive IT experience
5+ years in technology leadership

Salary/Compensations

$270,000-330,000
Eligible for an annual performance bonus

Benefits

Competitive medical, dental, and vision insurance
Mental health offerings
Equity incentive plan
401(k) program with employer match
Generous holiday and PTO policy

About the Company

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases.
Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease.
We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases.
We are fostering a culture that encourages vision, initiative and the development of talent.
Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work.
While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.