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About the Role
This role focuses on oligonucleotide therapeutics discovery, supporting RNAi-based research through synthesis, characterization, and collaboration across therapeutic areas.
Responsibilities
- Design and execute oligonucleotide synthesis and purification workflows.
- Perform HPLC and mass spectrometer analysis for characterization and impurity profiling.
- Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
- Develop and scale up synthesis of lead oligonucleotide candidates for pre clinical studies.
- Collaborate with cross-functional teams to integrate chemistry and biology data.
- Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
- Conduct literature reviews and contribute to experimental design and strategy.
Requirements
- BS/MS in Organic Chemistry or related field.
- Hands-on experience with oligonucleotide synthesis, purification, and characterization.
- Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
- Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.
Skills
- Oligonucleotide synthesis
- Oligonucleotide purification
- Oligonucleotide characterization
- HPLC
- Mass spectrometry
- RNAi
- Nucleic acid therapeutics
- Modification chemistries
Location
- South San Francisco, CA
Work Type
- Long Term Contract
Education Level
- BS/MS in Organic Chemistry or related field
Salary/Compensations
- $51/hr on W2
Benefits
- Medical
- Dental
- Vision
- Paid Sick leave
- 401K
About the Company
- Our client is a world leader in biotechnology and life sciences.