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About the Role
Seeking a motivated Scientist to join the Biochemical and Cellular Pharmacology team. This hands-on laboratory role will focus on developing and executing biochemical and cell-based induced-proximity assays to support the discovery and validation of novel therapeutic compounds. The scientist will analyze experimental data, troubleshoot assays, and collaborate with Pharmacology, Protein Science, Medicinal Chemistry, and Research Biology teams to advance early-stage drug discovery programs.
Responsibilities
- Develop and execute biochemical and cellular assays measuring protein–protein and protein–small molecule interactions.
- Design and perform induced-proximity assays supporting screening, lead identification, and compound validation.
- Analyze complex experimental datasets using GraphPad Prism, Python, R, or similar tools.
- Troubleshoot assay performance and optimize protocols for quality, reproducibility, and throughput.
- Present findings, prepare technical reports, and collaborate with multidisciplinary drug discovery teams.
Requirements
- B.S. or M.S. in Biochemistry, Biophysics, Cellular/Molecular Biology, or a related field.
- 1–3 years of hands-on laboratory experience in biotechnology, pharmaceutical, or academic research.
- Strong experience developing, validating, and executing cellular and biochemical assays.
- Direct experience with induced proximity, molecular glues, bivalent degraders, ternary complexes, or related modalities.
- Strong data analysis and interpretation skills with the ability to troubleshoot complex experimental systems.
Skills
- Protein biochemistry
- Recombinant protein expression
- Molecular biology
- Cell culture
- Western blot
- NanoBRET
- NanoBiT
- TR-FRET
- BRET
- Imaging-based assays
- Liquid handlers
- Plate washers
- Automated/semi-automated laboratory systems
- Drug discovery
- Screening
- Lead optimization programs
- Collaboration
- Communication
- Problem-solving
- Adaptability to changing research priorities
- GraphPad Prism
- Python
- R
Location
- South San Francisco, CA
Work Type
- Long-Term Contract
- Possibility Of Extension
Experience Level
- 1-3 years
Education Level
- B.S. or M.S.
Salary/Compensations
- $60 - $64/hr on W2
Benefits
- Medical
- Paid Sick Leave
- 401 (k)
About the Company
- Our client, a world leader in biotechnology and life sciences.