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About the Role

We are seeking a highly skilled Computational Biologist expert in biological data analysis and computational biology to leverage data for solving complex problems. You will collaborate with R&D and engineering teams, translating biological questions into computational solutions to build tools that advance scientific discovery and product development. This role is central to developing gene editing workflows, computational RNA design, and computational protein design, turning project work into productized capabilities. Approximately 10-15% of your time will be customer-facing.

Responsibilities

Design and evaluate guide RNAs across editing modalities.
Build and run on- and off-target validation analyses.
Quantify editing outcomes from sequencing data.
Design and optimize RNA sequences.
Model secondary structure, thermodynamic stability, and folding to inform design decisions.
Screen candidate sequences for proper characteristics before they reach the bench.
Apply structure prediction and modeling to engineer therapeutic and tool proteins.
Optimize variants for expression, stability, specificity, and reduced immunogenicity, and prioritize designs for experimental testing.
Work with ML/AI teammates to fold protein design models into Form Bio's platform.
Analyze large-scale biological datasets (e.g. genomics, transcriptomics, proteomics) to identify novel patterns and insights.
Design, implement, and maintain bioinformatics pipelines and workflows in Nextflow, Snakemake, or WDL for efficient, reproducible data processing.
Stay current with the latest bioinformatics algorithms, software, and databases.
Work with biologists, computational scientists, and software engineers to understand research needs and develop custom analytical tools.
Spend roughly 10-15% of your time in a customer-facing capacity.
Join scientific discussions with customer teams to scope problems, present results, and translate their questions into analyses.
Clearly communicate complex results and findings to both technical and non-technical audiences, and represent Form Bio's science credibly to external partners.
Execute NGS and long-read library preparation and sequencing runs (Illumina short-read; PacBio HiFi and/or Oxford Nanopore long-read).
Support amplicon, targeted panel, and whole-genome or whole-transcriptome workflows used for editing and design validation.
Own run QC and troubleshooting, and feed practical assay knowledge back into pipeline and experiment design.
Help close the loop between in silico design and empirical validation — designing the assay you will later analyze.

Requirements

Master's or Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related life sciences field.
Proven experience in a bioinformatician role, including analysis of multiomics datasets (RNA-Seq, WGS, ChIP-Seq, etc.).
Expertise in scripting languages such as Python or R.
Experience with NGS analysis and writing workflows in Nextflow, Snakemake, or WDL.
Solid understanding of biological principles, including molecular biology and genetics.
Hands-on experience in at least one of: gene editing analysis, computational RNA design, or computational protein design.
Willingness to spend approximately 10–15% of your time in a customer-facing role.
Based in the San Francisco Bay Area.
Experience across more than one of the three focus areas.
Familiarity with long-read sequencing data (PacBio, Oxford Nanopore) and the analysis challenges specific to it.
Hands-on NGS library prep and sequencer operation experience.
Experience with cloud computing platforms (e.g. AWS, GCP).
Experience with complex data visualization and data engineering.
Exposure to cell and gene therapy, CRISPR, mRNA, or AAV programs in an industry setting.
Prior experience presenting technical work to customers, collaborators, or external scientific partners.
Desire to work collaboratively across multi-functional departments, and to make decisions both collectively and independently.
Self-motivated, detail-oriented, and highly organized, with a drive to reach high-caliber milestones.
Roll-up-your-sleeves mentality; adaptable to start-up environments with competing deadlines and multiple deliverables.
Strong analytical, critical thinking, and problem-solving skills.
Strong verbal and written communication across mediums and audiences, with the poise to hold a scientific conversation with a customer and high emotional intelligence for building relationships at all levels, internally and externally.
Utmost integrity and understanding of confidentiality.
Comfortable in ambiguous situations and results focused; prior experience with fast-paced, early-stage, scaling organizations.

Skills

Python
R
Nextflow
Snakemake
WDL
NGS analysis
Multiomics datasets analysis
Gene editing analysis
Computational RNA design
Computational protein design
Long-read sequencing data analysis
Cloud computing platforms
Data visualization
Data engineering
Cell and gene therapy
CRISPR
mRNA
AAV programs
Scientific communication
Customer engagement

Location

San Francisco Bay Area

Work Type

Hybrid

Experience Level

Master's or Ph.D.
Proven experience in a bioinformatician role

Education Level

Master's or Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related life sciences field.

Salary/Compensations

$120,000–$140,000

About the Company

Form Bio provides award-winning AI and computational solutions for genetic medicine and synthetic biology leaders.
Form's solutions accelerate timelines from discovery to clinic by providing drug developers with rapid in silico characterization and optimization of their therapeutics followed by the lab validation.
Form Bio's proprietary patent protected AI models are the first of their kind, purpose-built to solve the most complex challenges in genetic engineering and design for gene and nucleic acid-based therapies.
With cross-disciplinary expertise spanning software engineering, biology, bioinformatics, AI, and data science, the Form Bio team collaborates closely with customers on their most pressing and strategic challenges and opportunities.
The team at Form Bio is committed, colorful, passionate, intelligent, collaborative, creative, experienced, scientific, and world-class.
Through it all, we maintain a culture of positivity, hope, happiness, and the belief that we're doing something formative.

Equal Opportunity

Form Bio strives to create an environment of mutual respect where equal employment opportunities are available to all applicants and team members without regard to race, color, religion, sex, pregnancy (including childbirth, lactation and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law.
Form Bio believes that diversity is paramount to our success, and we seek to recruit, develop, and retain the most talented people from a diverse candidate pool.
All employment is decided on the basis of qualifications, merit, and business need.