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About the Role
Lead cell-based assay development and execution on a dedicated night-shift schedule, focusing on generating reliable GPCR pharmacology data to inform compound decisions. Own assay quality, troubleshoot biological systems, and create clean handoffs for a continuous experimental loop.
Responsibilities
- Lead the design, execution, and optimization of cell-based GPCR assays, including calcium flux, cAMP, IP1/IP accumulation, beta-arrestin recruitment, receptor internalization, membrane potential, and related readouts.
- Develop robust workflows across transient and stable cell systems, optimizing culture conditions, plating density, receptor expression, stimulation formats, time courses, dose-response designs, and assay windows.
- Use fluorescence, luminescence, HTRF/TR-FRET, BRET, ELISA, plate-reader, imaging, and related methods to characterize potency, efficacy, selectivity, kinetics, bias, and reproducibility.
- Set assay controls, quality standards, and troubleshooting strategies that produce interpretable, decision-ready data.
- Investigate noisy curves, unusual plates, inconsistent biology, or compound results that do not make sense, and resolve root causes before problems repeat.
- Work closely with chemists and automation engineers to connect newly synthesized compounds to biological activity and prioritize the next experiments.
- Document overnight work and provide clear handoffs covering results, failures, decisions, and follow-up actions for the day team.
Requirements
- Able and willing to work the designated night-shift schedule reliably and make sound technical decisions independently when needed.
- Deep hands-on experience developing and running cell-based assays in cell biology, pharmacology, molecular biology, chemical biology, neuroscience, bioengineering, screening, or a closely related area.
- Strong experimental judgment and a systematic approach to assay troubleshooting, reproducibility, controls, and data interpretation.
- Experience with GPCR signaling assays such as calcium flux, cAMP, IP1/IP accumulation, beta-arrestin, or receptor trafficking is helpful but not required.
- The ability to set technical direction, improve workflows, and collaborate closely with chemistry and automation teams while remaining hands-on.
- Clear, disciplined documentation and communication across night-to-day handoffs.
Skills
- Cell-based assay development
- GPCR pharmacology
- Calcium flux assays
- cAMP assays
- IP1/IP accumulation assays
- Beta-arrestin recruitment assays
- Receptor internalization assays
- Membrane potential assays
- Fluorescence
- Luminescence
- HTRF/TR-FRET
- BRET
- ELISA
- Plate-reader operation
- Imaging
- Assay troubleshooting
- Data interpretation
- Documentation
- Communication
Location
- San Francisco
Work Type
- Night-shift schedule
- Full-time
Experience Level
- Senior
Salary/Compensations
- $500+ monthly wellness budget
- Generous equity options
- Healthy dinners provided daily
Benefits
- Medical coverage
- Dental coverage
- Vision coverage
- HSA
- FSA
- 401K plans
- Visa sponsorship
About the Company
- Vibrant and intensely mission-driven team.
- Members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
- Values speed and rigor, coupled with excitement, drive, and a strong work ethic.
- Early-stage environment valuing clarity, ownership, and follow-through.
- A place for ambitious, high-integrity people who want to become dramatically better.
- Surrounded by people who care intensely about the work and receive close feedback.
- Room to own increasingly important problems.
- Believes excellent work should be met with meaningful reward, ownership, and trust.
- Responsibility is earned through contribution, not title alone.
- Fast, transparent, and personal application process.
- International team with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.
Equal Opportunity
- Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.