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About the Role
You will lead medicinal-chemistry design and synthesis across Capable’s therapeutic programs, deciding which compounds to make and translating SAR and biological data into the next design cycle. You will remain hands-on from route selection through purification and characterization while owning the chemistry decisions that improve potency, selectivity, stability, exposure, tolerability, and efficacy.
Responsibilities
- Lead compound design and synthesis across small-molecule, peptide, and peptide-adjacent programs, from target-compound selection through biological handoff.
- Use SAR, in vitro, and in vivo data to prioritize and design next-round compounds.
- Design and execute practical synthetic routes using solution-phase or solid-phase workflows, functional-group transformations, coupling chemistry, protecting groups, and late-stage diversification as appropriate.
- Own synthesis, purification, characterization, quality control, documentation, and preparation of compounds for biological testing.
- Operate and help maintain key chemistry instrumentation, including HPLC, prep HPLC, LC-MS, microwave-assisted synthesis systems, and related analytical or purification platforms.
- Resolve difficult synthetic and analytical issues involving failed reactions, selectivity, side products, solubility, purification, recovery, or instrument performance.
- Partner closely with biology and pharmacology teams to connect chemistry decisions to potency, selectivity, stability, exposure, tolerability, and efficacy.
Requirements
- Five or more years of hands-on industry experience in medicinal or synthetic organic chemistry; peptide experience is helpful but not required.
- Strong medicinal-chemistry judgment and the ability to use SAR and biological data to decide what to make next.
- Experience owning chemistry end to end, including compound design, route selection, synthesis, purification, characterization, quality control, and biological handoff.
- Deep troubleshooting ability and a high bar for clean experimental execution and documentation.
- Comfort working close to biological readouts and balancing potency, selectivity, stability, exposure, tolerability, efficacy, and practical synthesis.
- The ability to provide technical direction and raise the quality of a program while remaining hands-on.
Skills
- Medicinal Chemistry
- Synthetic Organic Chemistry
- Peptide Chemistry
- SAR analysis
- In vitro data analysis
- In vivo data analysis
- Solution-phase synthesis
- Solid-phase synthesis
- Functional-group transformations
- Coupling chemistry
- Protecting groups
- Late-stage diversification
- Purification
- Characterization
- Quality control
- Documentation
- HPLC
- Prep HPLC
- LC-MS
- Microwave-assisted synthesis
- Troubleshooting
- Experimental execution
Location
- San Francisco
Work Type
- Onsite
- Full-time
Experience Level
- Five or more years of hands-on industry experience
Salary/Compensations
- Compensation will depend on the skills, experience, and scope of impact you bring.
Benefits
- Generous equity options
- $500+ monthly wellness budget
- 100% employer-covered medical, dental, and vision coverage
- HSA, FSA, and 401K plans
- Healthy dinners provided daily
- Visa sponsorship available
About the Company
- We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
- We value speed and rigor, coupled with excitement, drive, and a strong work ethic.
- In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
- Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.
- You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.
- We believe excellent work should be met with meaningful reward, ownership, and trust.
- Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope.
Equal Opportunity
- Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.