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About the Role
You will lead the design, execution, and interpretation of mouse studies to evaluate therapeutic candidates for efficacy, pharmacology, and safety. You will make data-driven decisions regarding next steps and candidate selection.
Responsibilities
- Design, run, and interpret mouse studies evaluating therapeutic candidates across efficacy, pharmacology, and safety.
- Select appropriate dose, route, schedule, tissues, timepoints, endpoints, controls, and go/no-go criteria for each study.
- Perform and guide dosing by routes including IP, IV, SC, PO, intranasal, and other relevant methods.
- Perform or oversee in-life work, blood collection, necropsy, tissue collection, sample tracking, surgeries, and specialized procedures.
- Analyze PK/PD, efficacy, tolerability, biomarker, and tissue data to determine next steps.
- Design and execute EEG studies where required, including surgery, electrode placement, monitoring, and electrophysiological-data processing.
- Coordinate with downstream molecular, histology, and biomarker workflows and turn each dataset into the next well-controlled experiment.
Requirements
- Substantial hands-on experience designing and running mouse studies in biotech, pharma, academia, or a closely related setting.
- Strong translational judgment: ability to design studies that test tissue exposure, target engagement, pathway modulation, phenotype, and tolerability.
- Comfort with multi-route dosing, in-life execution, necropsy, tissue and blood collection, sample tracking, and coordination with downstream assays.
- Ability to interpret PK/PD and efficacy data and make disciplined next-study or candidate decisions.
- A fast, rigorous working style with explicit hypotheses, dose rationale, endpoints, controls, and go/no-go criteria.
- Prior experience with every route, procedure, or assay listed is not required.
Skills
- PK/PD analysis
- Efficacy analysis
- Tolerability analysis
- Biomarker analysis
- Tissue data analysis
- EEG study design
- Surgery
- Electrode placement
- Electrophysiological data processing
- Molecular workflows
- Histology workflows
- Biomarker workflows
Location
- San Francisco
Work Type
- Onsite
- Full-time
Experience Level
- Early-stage environment experience
Benefits
- Generous equity options
- $500+ monthly wellness budget
- 100% covered medical, dental, and vision coverage
- HSA, FSA, and 401K plans
- Healthy dinners provided daily
- Visa sponsorship
About the Company
- Vibrant and intensely mission-driven team.
- Members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
- Values speed and rigor, coupled with excitement, drive, and a strong work ethic.
- Values people who can bring clarity to open-ended problems, take ownership, and follow through with energy.
- A place for ambitious, high-integrity people who want to become dramatically better.
- Surrounds employees with people who care intensely about the work and provide close feedback.
- Offers room to own increasingly important problems.
- Believes excellent work should be met with meaningful reward, ownership, and trust.
- Responsibility is earned through contribution, not title alone.
- Fast, transparent, and personal application process.
- International team with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.
Equal Opportunity
- Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.