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About the Role
You will lead synthetic execution across Capable’s small-molecule, peptide, and adjacent therapeutic programs. You will turn target structures into confirmed, test-ready compounds by choosing practical routes, solving difficult reaction and purification problems, and building reliable chemistry workflows. This is a senior hands-on role centered on excellent synthesis and material delivery.
Responsibilities
- Lead organic-chemistry execution from target-compound selection through route design, synthesis, purification, characterization, quality control, and biological handoff.
- Design and execute practical routes using solution-phase and solid-phase methods, functional-group transformations, coupling chemistry, protecting-group strategies, and late-stage diversification.
- Own the delivery of the right compounds with confirmed identity, purity, yield, documentation, and readiness for biological testing.
- Operate and help maintain key chemistry instrumentation, including HPLC, prep HPLC, LC-MS, microwave-assisted synthesis systems, and related platforms.
- Resolve difficult synthetic and analytical issues involving failed reactions, conversion, selectivity, side products, deprotection, solubility, purification, recovery, and instrument downtime.
- Work with biology and pharmacology teams to prioritize compounds using SAR, potency, stability, exposure, tolerability, and efficacy data while remaining anchored in practical chemistry execution.
- Improve routes, analytical methods, documentation, and laboratory workflows so high-quality material can be produced faster and more reliably.
Requirements
- Five or more years of hands-on industry experience in synthetic organic, medicinal, peptide, or closely related chemistry; peptide experience is helpful but not required.
- Strong synthetic judgment and the ability to turn a target structure into a confirmed, biologically testable compound.
- Experience owning route selection, synthesis, purification, characterization, quality control, documentation, and biological handoff.
- Deep troubleshooting ability across reactions, purification, analytical methods, and laboratory instrumentation.
- Comfort working close to biological readouts while keeping primary ownership of practical chemistry execution.
- The ability to provide technical direction, improve team workflows, and remain directly involved in the hardest experiments.
Skills
- Synthetic organic chemistry
- Medicinal chemistry
- Peptide chemistry
- Route design
- Synthesis
- Purification
- Characterization
- Quality control
- HPLC
- Prep HPLC
- LC-MS
- Microwave-assisted synthesis
- Solution-phase methods
- Solid-phase methods
- Functional-group transformations
- Coupling chemistry
- Protecting-group strategies
- Late-stage diversification
- Troubleshooting
- Analytical methods
Location
- San Francisco
Work Type
- Onsite
- Full-time
Experience Level
- Senior
- Five or more years of industry experience
Salary/Compensations
- Compensation will depend on the skills, experience, and scope of impact you bring.
Benefits
- Generous equity options
- $500+ monthly wellness budget
- 100% employer-covered medical, dental, and vision coverage
- HSA, FSA, and 401K plans
- Daily healthy dinners with the team
- Visa sponsorship available
About the Company
- We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
- We value speed and rigor, coupled with excitement, drive, and a strong work ethic.
- In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy.
- Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better.
- You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems.
- We believe excellent work should be met with meaningful reward, ownership, and trust.
- Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope.
- Our process is fast, transparent, and personal. We care about getting to know the person behind the application.
- Our team is already international, with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.
Equal Opportunity
- Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.