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About the Role
You will lead peptide-chemistry execution on a dedicated night-shift schedule, keeping synthesis, purification, characterization, and biological handoffs moving around the clock. You will make sound technical decisions independently, solve difficult chemistry and instrument problems, and ensure the day team receives complete, decision-ready work each morning.
Responsibilities
- Lead overnight peptide synthesis from route or sequence planning through reaction setup, solid- or solution-phase synthesis, cleavage, purification, characterization, and sample preparation.
- Run and optimize microwave-assisted solid-phase peptide synthesis, including resin loading, coupling and deprotection cycles, crude analysis, and final quality control.
- Resolve difficult overnight issues involving failed reactions, low conversion or purity, side products, solubility, cleavage or deprotection, purification, and instrument downtime.
- Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, and related methods as appropriate.
- Own identity, purity, yield, analytical traces, batch records, and sample readiness for in vitro and in vivo testing.
- Contribute chemistry insight on feasibility, SAR, stability, solubility, yield, and structure-property relationships to guide the next compounds.
- Provide disciplined morning handoffs covering results, failures, technical decisions, sample locations, risks, and follow-up actions.
Requirements
- Able and willing to work the designated night-shift schedule reliably and make consequential technical decisions independently when needed.
- Five or more years of hands-on industry experience in peptide, medicinal, organic, or closely related chemistry.
- Strong synthetic-chemistry fundamentals, experimental judgment, and deep troubleshooting ability; direct peptide experience is helpful.
- Experience owning chemistry end to end, including design, synthesis, purification, characterization, quality control, and preparation for biological testing.
- A fast, rigorous, and safety-conscious working style with excellent experimental records.
- The ability to lead through technical judgment and create clean, useful handoffs across night and day teams.
Skills
- Peptide synthesis
- Solid-phase peptide synthesis
- Microwave-assisted synthesis
- Analytical HPLC
- Preparative HPLC
- LC-MS
- NMR
- Troubleshooting
- Experimental design
- Quality control
- Route planning
- Sequence planning
Location
- San Francisco
Work Type
- Night shift
- Full-time
Experience Level
- Five or more years of industry experience
Salary/Compensations
- Compensation will depend on the skills, experience, and scope of impact you bring.
Benefits
- Generous equity options
- $500+ monthly wellness budget
- 100% covered medical, dental, and vision coverage
- HSA, FSA, and 401K plans
- Healthy dinners provided daily
- Visa sponsorship available
About the Company
- Vibrant and intensely mission-driven team
- Members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber
- Values speed and rigor, coupled with excitement, drive, and a strong work ethic
- Early-stage environment
- Place for ambitious, high-integrity people who want to become dramatically better
- Surrounded by people who care intensely about the work
- Receive close feedback from people making scientific and company-defining decisions
- Room to own increasingly important problems
- Believe excellent work should be met with meaningful reward, ownership, and trust
- Responsibility is earned through contribution, not title alone
- International team with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States
Equal Opportunity
- Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.