Impress employers and recruiters.
Choose from hundreds of resume examples.

Target Resume Now

Tailor your resume to this (Senior / Principal) Scientist, RNA Therapeutics role.

Rezi rewrites your resume against Capable Labs's job description. Free.

Resume score gauge reading 58 out of 100

Don't guess if your resume is good enough.

See how it scores against the (Senior / Principal) Scientist, RNA Therapeutics posting at Capable Labs — free, in seconds.

About the Role

Lead RNA-therapeutics programs from target biology and oligonucleotide design through chemistry selection, assay strategy, quality control, and in vivo validation. Build coherent programs by connecting mechanism, tissue, potency, durability, safety, and manufacturability to clear experimental decisions in this senior hands-on role with end-to-end scientific ownership.

Responsibilities

Lead the design of ASOs, siRNAs, splice-switching oligonucleotides, gapmers, steric-blocking oligonucleotides, and other RNA-targeting molecules.
Select oligonucleotide chemistries based on tissue, mechanism, potency, durability, safety, off-target risk, immune activation, and manufacturability.
Develop sequence strategies for RNase H knockdown, splice modulation, translation blocking, miRNA inhibition, transcript stabilization, and other RNA-level mechanisms.
Refine design rules involving GC content, RNA secondary structure, isoform selectivity, SNPs, conservation, and specificity.
Source, synthesize, purify, and quality-control oligonucleotides using appropriate methods.
Design and interpret assays for knockdown, splice correction, transcript and protein changes, pathway modulation, cell viability, immune activation, and in vivo tissue target engagement.
Build the complete program package: target rationale, sequence set, chemistry plan, assay strategy, quality-control data, in vitro and in vivo results, failure modes, and next-step logic.
Set technical direction, bring in outside expertise where useful, and remain directly involved in the experiments and data that determine program decisions.

Requirements

Deep hands-on experience with RNA therapeutics, ASOs, siRNA, splice-switching oligonucleotides, RNA biology, nucleic-acid chemistry, pharmacology, or closely related work.
Ability to reason from target biology to sequence and chemistry design to the assay readout that will validate or reject the approach.
Experience designing and interpreting RNA-therapeutics assays at transcript, protein, pathway, cellular, or in vivo tissue level.
Experience with methods such as qPCR, ddPCR, RNA-seq, western blot, ELISA, reporter assays, splice assays, cytokine panels, or tissue analysis is helpful; expertise in every method is not required.
A rigorous, efficient, and resourceful approach to moving a program forward when sequences, assays, models, tissue analysis, or outside capabilities are missing.
Ability to provide technical leadership while staying close to hands-on work and primary data.

Skills

RNA therapeutics
ASOs
siRNA
Splice-switching oligonucleotides
RNA biology
Nucleic-acid chemistry
Pharmacology
Oligonucleotide design
Assay development
Quality control
In vivo validation
Sequence selection
Chemistry selection
HPLC/UPLC
LC-MS
MALDI
UV quantification
PAGE
Endotoxin/bioburden testing
Batch-level analytical tracking
qPCR
ddPCR
RNA-seq
Western blot
ELISA
Reporter assays
Splice assays
Cytokine panels
Tissue analysis

Location

San Francisco

Work Type

Onsite
Full-time

Experience Level

Senior

Salary/Compensations

Compensation will depend on the skills, experience, and scope of impact you bring. If your background, experience, or compensation needs fall outside this range, we are still open to a conversation based on the scope and impact you could bring.

Benefits

Generous equity options
$500+ monthly wellness budget
100% covered medical, dental, and vision coverage
HSA, FSA, and 401K plans
Healthy dinners provided daily
Visa sponsorship available

About the Company

Vibrant and intensely mission-driven team.
Members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.
Values speed and rigor, coupled with excitement, drive, and a strong work ethic.
Early-stage environment valuing clarity, ownership, and follow-through.
A place for ambitious, high-integrity people who want to become dramatically better.
Surrounded by people who care intensely about the work and receive close feedback.
Room to own increasingly important problems.
Believes excellent work should be met with meaningful reward, ownership, and trust.
Responsibility is earned through contribution, not title alone.
Fast, transparent, and personal application process.
International team with members from Canada, Pakistan, Germany, Austria, Switzerland, China, India, and the United States.

Equal Opportunity

Capable is an Equal Opportunity Employer; employment with Capable is governed on the basis of merit, competence and qualifications and will not be influenced in any manner by race, color, religion, gender, national origin/ethnicity, veteran status, disability status, age, sexual orientation, gender identity, marital status, mental or physical disability or any other legally protected status.