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About the Role
Xaira Therapeutics is seeking a Principal Associate Scientist for the Bioanalytical Sciences team. This hands-on, lab-based role involves developing and executing ligand binding assays to support pharmacokinetic, pharmacodynamic, and target engagement studies in discovery and translational programs. The position is ideal for individuals with strong bioanalytical assay development and execution experience who enjoy bench work and contributing to data generation in a fast-paced, collaborative environment.
Responsibilities
- Develop, optimize, and execute ligand binding assays (ELISA, MSD/ECL) and flow cytometry-based methods to support PK, PD, receptor occupancy, and target engagement studies for biologic programs
- Support assay development, optimization, qualification, and validation activities for non-GLP, IND-enabling GLP, and clinical studies
- Contribute to the design and execution of DMPK and bioanalytical studies, generating PK/PD and exposure data to support candidate selection
- Support bioanalytical method development, qualification, and validation for discovery, translational, and clinical programs
- Process and analyze samples across NHP and rodent matrices, including serum, plasma, and tissue
- Generate, analyze, and clearly document experimental data to support team decision-making
- Prepare presentations and data summaries to communicate experimental findings with internal program groups and external CROs
- Maintain accurate lab records and ensure reproducibility of experimental workflows
- Collaborate with cross-functional teams to support ongoing research programs
Requirements
- B.S. or M.S. in Biochemistry, Immunology, Analytical Chemistry, or a related field
- 7+ years of relevant industry experience
- Strong hands-on experience with ligand binding assay platforms (ELISA, MSD/ECL)
- Proven experience executing flow cytometry-based assays, ideally for receptor occupancy or target engagement
- Experience supporting PK/PD sample analysis across NHP and/or rodent species in a discovery or translational research setting
- Ability to independently execute experiments and troubleshoot technical issues
- Past experience with summarizing data and presenting to internal or external groups
- Strong attention to detail, organization, and record keeping
- Ability to work effectively in a fast-paced, team-oriented environment
Skills
- Ligand binding assay development
- ELISA
- MSD/ECL
- Flow cytometry
- Receptor occupancy
- Target engagement
- PK/PD sample analysis
- Data analysis
- Data presentation
- Record keeping
Location
- San Francisco Bay Area
- Seattle
- London
Work Type
- Lab-based
- Full-time
Experience Level
- Principal Associate Scientist
- 7+ years of relevant industry experience
Education Level
- B.S. or M.S. in Biochemistry, Immunology, Analytical Chemistry, or a related field
Salary/Compensations
- $110,000 to $138,000 annually
Benefits
- Competitive compensation and benefits package
- Open, flexible, and friendly work environment
- Platform to develop long-term careers
- Base salary, bonus, and equity
About the Company
- Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
- The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
- It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
- Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.
Equal Opportunity
- Xaira Therapeutics an equal-opportunity employer.
- We believe that our strength is in our differences.
- Our goal to build a diverse and inclusive team began on day one, and it will never end.