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About the Role

Twist is searching for an R&D scientist/manager with experience in cell biology and protein expression and purification, with an emphasis on antibodies, to lead and enhance our protein sciences capabilities. You will operate as both a hands-on bench scientist and a builder of people and process, starting as an individual contributor while defining the technical roadmap, hiring, and building a team.

Responsibilities

• Develop small- and medium-scale antibody production workflows, including various formats, culture systems, and purification methods.
• Improve all aspects of the end-to-end antibody development workflow: construct design, cell line development, cell culture, purification, and analytics.
• Build from the ground up and manage a team of scientists and RAs.
• Independently design and execute experiments, and analyze experimental data.
• Move projects forward efficiently, manage time and resources effectively, and prioritize tasks in accordance with the company’s goals.
• Document and communicate results clearly and succinctly.
• Be helpful, collaborative, and proactive.
• Stay up to date with new developments, companies, and technologies.
• Be the ultimate subject matter expert, and understand all aspects of your work profoundly.

Requirements

• Deep hands-on experience designing, expressing, and optimizing monoclonal antibodies, with demonstrated understanding of Fc structure–function relationships.
• Proven experience with bispecific antibody architectures, including knob-in-hole, CrossMab, common light chain, or similar.
• Experience with chain pairing control and mispairing mitigation.
• Experience generating and optimizing stable mammalian cell lines (CHO preferred), including vector design, promoter/selection strategies, clone screening, productivity optimization, and stability assessment.
• Strong understanding of transient vs stable expression tradeoffs.
• Experience improving expression yields and product quality through sequence, vector, and host engineering.
• Demonstrated ability to build, improve, and standardize antibody generation workflows.
• Experience developing high-throughput or semi-automated workflows for expression, purification, and screening.
• Strong understanding of platform robustness, reproducibility, and cost drivers.
• Hands-on experience with antibody characterization methods, such as SEC, CE-SDS, binding kinetics (BLI or SPR), and basic biophysical profiling (DSF, DLS).
• Strong mechanistic understanding of antibody biology, structure, and expression bottlenecks.
• Experience designing platforms that support multiple antibody modalities (mAbs, bispecifics, Fc-engineered variants).
• A track record of successful and creative method development.
• Experience with liquid-handling systems and automation is a plus.
• Familiarity with Python or equivalent programming languages is a plus.

Skills

• Cell biology
• Protein expression
• Protein purification
• Antibodies
• Monoclonal antibodies
• Bispecific antibody architectures
• Mammalian cell line generation
• CHO cell culture
• Antibody characterization
• Method development

Location

• South San Francisco, CA

Work Type

• Full-time

Experience Level

• 5+ years of experience in protein sciences
• 5 years of management experience

Education Level

• PhD in Cell Biology, Biochemistry, or a closely related field

Salary/Compensations

• $189,000—$224,000 USD

Benefits

• Bonus
• Equity
• Generous benefits package

About the Company

• Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. The next phase of development for the genomics revolution is the ability to write DNA.
• At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Equal Opportunity

• Twist Bioscience Corporation is an Equal Opportunity Employer.
• Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.