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About the Role

Xaira Therapeutics is seeking a lab-based Senior Scientist in Inflammation and Immunology to join our Biology & Pharmacology department. This role is ideal for someone who thrives in a hands-on research environment, has experience working with primary human and mouse immune cells, including ex vivo tissue systems, and is excited to help shape therapeutic program strategy. In this role, you will investigate disease biology and drug mechanisms, generate actionable data, and intellectually contribute to advancing therapeutic programs through cross-functional collaborations.

Responsibilities

Drive preclinical programs by designing, executing and analyzing in vitro and in vivo studies that explore disease biology, target validation, and lead candidate development.
Identify knowledge gaps, ask critical mechanistic questions to guide program direction, and evaluate novel targets and therapeutic strategies.
Dissociate human and mouse tissues into single-cell suspensions and/or establish tissue cultures for downstream functional or phenotyping assays including immune profiling, functional assays.
Translate experimental data into actionable insights and clearly communicate findings and recommendations to cross-functional teams.

Requirements

PhD in Immunology or a related field with 3+ years of relevant experience.
Track record of impact through first author publications, posters and presentations at meetings.
Hands-on experience with primary human and mouse immune cells.
Strong expertise in flow cytometry, including high-parameter panel design, execution, and data analysis.
Proven ability to independently plan, execute, troubleshoot, and interpret experiments.
Excited about employing AI tools in every aspect of everyday work.
Highly organized and precise in record keeping, with the ability to manage multiple workstreams in a fast-paced environment.
Clear communicator who can distill complex data into actionable insights.

Skills

High-parameter flow cytometry (15+ colors)
ELISA
MSD
Luminex
qPCR
RNAseq analyses
Antigen presentation assays
Immune cell activation assays
Immune cell differentiation assays
Immune cell proliferation assays
Immune cell suppression assays
Immune cell migration assays
AI tools

Location

San Francisco Bay Area
Seattle
London

Work Type

Lab-based
Full-time

Experience Level

Senior Scientist
3+ years of relevant experience

Education Level

PhD in Immunology or a related field

Salary/Compensations

$140,000 - $170,000 annually

Benefits

Competitive compensation and benefits package
Open, flexible, and friendly work environment
Platform to develop long-term careers
Base salary
Bonus
Equity

About the Company

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development.
The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets.
It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification.
Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development.

Equal Opportunity

Xaira Therapeutics an equal-opportunity employer.
We believe that our strength is in our differences.
Our goal to build a diverse and inclusive team began on day one, and it will never end.