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About the Role

Syndax Pharmaceuticals is seeking an Executive Director, Asset Strategy Lead and Clinical Lead, Early Development to provide leadership to a cross-functional strategic asset team and lead the development and execution of the asset strategy. This role will also serve as the clinical lead for the Next Generation Menin Program during its early stages of development and will be a key member of the senior leadership team, influencing portfolio strategy and execution.

Responsibilities

Own end-to-end leadership of the asset strategy, from early development through regulatory filings, approval, launch, and lifecycle management.
Drive the strategic direction of the program in alignment with corporate objectives, balancing scientific innovation, clinical value, and commercial opportunity.
Identify potential issues and lead contingency planning; lead AST problem solving and apply decision-making tools and techniques.
Drive AST to make effective and efficient decisions.
Serve as a key liaison to the Executive Leadership Team, providing updates, insights, and recommendations that inform enterprise decisions.
Lead long-range planning, including scenario planning, investment strategy, and external innovation assessments related to the asset.
Partner with Commercial, Medical Affairs, Regulatory, and Development to shape Target Product Profile (TPP) and ensure robust lifecycle and global expansion planning.
Lead resolution of conflict at the AST and oversee governance engagement, ensuring timely and transparent communication on key decisions, risks, budgets, and timelines.
Foster a culture of accountability, innovation, and excellence, modeling strong leadership and collaborative behaviors.
Represent Syndax in strategic partnerships, collaborations, and scientific/medical forums as appropriate.

Requirements

A minimum of 10 or more years of experience in leading clinical development programs in oncology is required.
Equivalent experience in a leadership role as a part of a research-driven pharmaceutical company is required.
Proven track record of successfully leading global cross-functional teams through IND, early development and pivotal studies; experience with BLA/NDA and launch phases is a plus.
Deep knowledge of oncology product development, regulatory environments, and commercialization strategies.
Strong strategic acumen with the ability to anticipate market dynamics and influence enterprise-level decisions.
Prior experience interacting with C-suite executives, external partners, and regulators.
Highly collaborative, with strong influencing skills and ability to work across multiple levels and functions.
Executive presence and outstanding communication skills, including comfort presenting to senior and external audiences.
Experience with portfolio management, financial modeling, and program valuation is highly desirable.

Skills

Strategic leadership
Operational excellence
Global oncology product development
Early-stage program leadership
Pre-IND activities
Pivotal studies
Regulatory approval
Commercialization
Portfolio strategy
Scientific integration
Clinical integration
Regulatory integration
Commercial integration
Financial integration
Asset value optimization
Contingency planning
Problem-solving
Decision-making
Long-range planning
Scenario planning
Investment strategy
External innovation assessment
Target Product Profile (TPP) shaping
Lifecycle planning
Global expansion planning
Conflict resolution
Governance engagement
Communication
Accountability
Innovation
Excellence
Collaboration
Influencing skills
Executive presence
Presenting to senior and external audiences
Portfolio management
Financial modeling
Program valuation

Location

New York, NY

Work Type

Onsite

Experience Level

Executive Director
10+ years of experience

Education Level

Advanced degree in life sciences, medicine, or business (e.g., PhD, MD, MBA) highly preferred.

Salary/Compensations

$370,000 - $400,000

Benefits

Equity offering
Annual target bonuses
Outstanding benefits program

About the Company

Syndax Pharmaceuticals is a commercial-stage biopharmaceutical company advancing innovative cancer therapies.
Highlights of the Company’s pipeline include a menin inhibitor for R/R acute leukemia and a monoclonal antibody that blocks the CSF-1 receptor for chronic graft-versus-host disease.
Fueled by our commitment to reimagining cancer care, Syndax is working to unlock the full potential of its pipeline and is conducting several clinical trials across the continuum of treatment.
For more information, please visit www.syndax.com/ or follow the Company on X and LinkedIn.

Equal Opportunity

Syndax Pharmaceuticals is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.