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About the Role

This project involves designing and performing experiments using embryonic stem cells differentiation models and mouse, chick and human embryos to investigate cell fate decision making mechanisms controlling neuronal cell diversity in the spinal cord. The research aims to understand how this governs cell fate choices by regulating chromatin accessibility and gene expression in neural progenitors.

Responsibilities

• Design, plan and execute experimental studies using embryonic stem cell differentiation systems and mouse, chick and human embryo models.
• Generate, analyse and interpret molecular, cellular and genomic datasets, including assays of gene regulation, transcription factor activity and chromatin accessibility.
• Maintain accurate experimental records and ensure data are managed and documented to institute standards.
• Develop and apply computational approaches for the analysis and interpretation of experimental data.
• Drive an independent research project investigating mechanisms controlling neuronal cell diversity in the spinal cord and contribute to the wider research programme of the lab.
• Present findings at lab meetings, institute seminars and external scientific conferences, and prepare manuscripts for publication.
• Collaborate with colleagues within the Crick and with external research partners.
• Contribute to the supervision and mentoring of students and junior researchers where appropriate.
• Assist in the development of new experimental approaches and research directions relevant to the laboratory's objectives.

Requirements

• PhD submitted or recently completed
• Good knowledge and experience in relevant scientific area(s)
• Relevant technical expertise
• Evidence of writing papers e.g. as publications or submitted manuscripts in referred journals
• Evidence of data presentation at scientific meetings
• Experience of experimental design
• Ability to work independently and also capable of interacting within a group

Skills

• Developmental biology (desirable)
• Generating and analysing epigenetic and gene regulatory data (desirable)

Location

• UK

Work Type

• Full-time
• Fixed term (4 years)

Experience Level

• Postdoctoral

Education Level

• PhD

Salary/Compensations

• From £47,500

Benefits

• Sponsorship to work in the UK
• 28 days of annual leave, plus three additional days over Christmas and bank holidays
• Defined contribution pension with employer contributions of up to 16%
• 24/7 GP consultation services
• Occupational health services and mental health support programs
• Eye care vouchers and discounted healthcare plans
• Back-up care for dependents
• Childcare support allowance
• Annual leave purchase options
• Crick Networks offering diverse groups’ support, community and inclusive social events
• Discounted gym memberships
• Bike-to-work scheme
• Shopping discounts
• Subsidised on-site restaurant and social spaces for team interaction

About the Company

• The Francis Crick Institute is Europe’s largest biomedical research institute under one roof.
• Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
• The Crick is a place for collaboration, innovation and exploration across many disciplines.
• A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions.
• We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture.
• We’ve removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher.
• This gives us the freedom to take risks and carry out high-quality, pioneering research.
• Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

Equal Opportunity

• At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery.
• We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances.
• We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences.
• We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply.
• If you need assistance with applying (i.e., would like to apply by phone or post) please email: karen.au@crick.ac.uk