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About the Role

The Molecular Profiling and Drug Delivery (MPDD) function within Small Molecule CMC is responsible for a wide range of deliverables throughout drug discovery and development. MPDD scientists use advanced automation and computational tools, combined with expertise in biopharmaceutics, drug delivery, and solid-state chemistry, to advance candidates with a higher probability of success into development and guide clinical formulation strategy. They also identify commercial solid forms of APIs, establish structure-property-performance correlations, and ensure robust commercial processes and aligned control strategies. Drug Delivery scientists conduct developability assessments, profile physicochemical properties, develop preclinical formulations, address in vivo absorption challenges, and advance novel drug delivery strategies for various administration routes. This role involves working in cross-functional teams in matrixed environments and engaging in multidisciplinary problem-solving.

Responsibilities

Contribute to the profiling of physiochemical properties.
Screen and develop preclinical formulations.
Advance platform workflows for emerging modalities of interest.
Build and optimize integrated capabilities that support faster, data-driven, more efficient pipeline progression.
Work closely with cross-functional partners across discovery and development sciences.
Identify the commercial solid form of the active pharmaceutical ingredient (API).
Establish structure-property-performance correlations.
Deliver robust commercial processes and align control strategies across drug substance and product.
Transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites.
Ensure successful regulatory submissions within teams.

Requirements

Bachelor’s Degree or equivalent education with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience in pharmaceutical or related industry.
Familiarity and preferred hands-on experience in physicochemical property assessment related to understanding CMC developability profile and potential risk mitigation strategies.
Hands-on Experience with HPLC–MS, high-resolution mass spectrometry, or related analytical platforms.
Hands-on experience in assay development, automation, and workflow optimization, with an ability to design and implement efficient, reproducible, and scalable laboratory processes.
Strong understanding of physiochemical property profiling and its application to early developability assessment, including methods relevant to solubility, stability, and other compound attributes that inform pipeline decisions.
Familiarity with preclinical formulation development and screening strategies, including support for enabling formulations for emerging or complex modalities.
Familiarity with analytical, biophysical, and in vitro techniques used to generate high-quality data for early development decision making.
Experience collaborating with data scientists, computational chemists, or informatics partners.
Excellent organizational skills, self-management, and attention to detail, with the ability to manage multiple priorities in a fast-paced environment.

Skills

Assay development
Chemical automation
Integrated workflow design
Analytical chemistry
HPLC–mass spectrometry (HPLC–MS)
Laboratory automation
Automated and data-enabled workflows
Physiochemical property profiling
Preclinical formulation screening and development
Platform workflows for emerging modalities
Plate-based optical spectroscopy
Liquid handler operation
Custom scientific programming and scripting
Machine learning and model-building concepts
High-performance liquid chromatography (HPLC)
Mass spectrometry
Powder X-ray diffraction (pXRD)
Optical microscopy
Light scattering techniques
Thermal analysis
Biophysical characterization techniques
Automated data capture
Laboratory instrumentation integration
Assay miniaturization
Data analysis workflows
High-resolution mass spectrometry
Workflow optimization
Solubility assessment
Stability assessment
Enabling formulations for emerging or complex modalities
Analytical techniques
Biophysical techniques
In vitro techniques
Scientific curiosity
Problem-solving ability

Work Type

Full-time

Experience Level

Associate Scientist I
5 years of experience (Bachelor's)
2 years of experience (Master's)

Education Level

Bachelor’s Degree or equivalent
Master’s Degree or equivalent
Pharmaceutical Sciences
Pharmaceutical Engineering
Chemical/Biomedical Engineering
Chemistry
Materials Science

Benefits

Paid time off (vacation, holidays, sick)
Medical/dental/vision insurance
401(k)
Short-term incentive programs

About the Company

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow.
We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio.

Equal Opportunity

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.
Equal Opportunity Employer/Veterans/Disabled.