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About the Role

Regeneron is seeking a Principal Scientist to join their Genetic Medicines team, focusing on advancing the preclinical development of targeted genetic medicines for central nervous system disorders. This role involves designing and leading experiments in CNS disease models within a collaborative, multidisciplinary team.

Responsibilities

• Design experiments to evaluate the efficacy, target engagement, and delivery efficiency of viral and non-viral therapeutic candidates across CNS disease models
• Design AAV transgene cassettes to optimize therapeutic efficacy
• Lead a team of associates in the execution of experiments and analysis of primary data
• Interpret complex datasets, integrating findings with current scientific literature to propose data-driven next steps
• Communicate project strategy, scientific vision, and data updates to senior leaders
• Author and review preclinical study reports to support regulatory submissions
• Approach scientific problems with an engineering mindset and a design-build-test-learn framework
• Coach and mentor junior scientists within a multidisciplinary team environment

Requirements

• Experience evaluating DNA- or RNA-based therapeutics in small-animal models
• Hands-on experience with molecular biology techniques
• Experience mentoring and managing research associates
• Excellent communication and presentation skills

Skills

• Neuroscience
• Gene therapy
• Biotechnology
• Genetic medicines
• CNS drug discovery
• Viral delivery modalities
• Non-viral delivery modalities
• Molecular biology techniques

Location

• Tarrytown, NY

Work Type

• Onsite

Experience Level

• 5+ years of combined postdoctoral and industry experience

Education Level

• Ph.D. in neuroscience, gene therapy, or a related discipline

Salary/Compensations

• $128,600.00 - $210,000.00

Benefits

• Annual bonuses or other incentive plans
• Equity awards
• Pension or retirement benefits
• 401(k) company match
• Health and wellness programs
• Fitness centers
• Insurance benefits (e.g. medical, dental, vision, life and disability)
• Paid time off
• Family support benefits

About the Company

• Regeneron uses science and innovation to develop life-changing medicines for people with serious diseases.
• We are committed to building a workplace with an inclusive culture.

Equal Opportunity

• Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.
• Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.