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About the Role

Basecamp Research is seeking individuals passionate about developing extraction and sequencing workflows to enhance data generation. This role involves building DNA/RNA pipelines with a focus on metagenomic recovery from diverse sample types and utilizing sequencing workflows from extraction to library preparation, including short and long-read technologies and HMW extraction.

Responsibilities

• Align and prioritize R&D projects with the R&D Lead, Director of Production, and wider teams.
• Develop and optimize metagenomic extraction methods for various sample types, including low-biomass and inhibitor-rich matrices.
• Develop DNA/RNA purification methods for viruses and microbes, including HMW extractions for long-read sequencing.
• Apply and develop virology-focused workflows from extraction to sequencing.
• Design experiments to compare extraction chemistries, sample processing, library preparation, and sequencing performance.
• Define success criteria, generate validation data, and support method transfer to production.
• Prioritize development work based on scientific value, data generation impact, feasibility, and timelines.
• Work confidently within a CLS 2 environment and with genetically modified organisms.
• Implement or develop novel methods for library building for Next Generation Sequencing.
• Work collaboratively within multi-disciplinary teams as a project lead or team member.
• Analyze experiments and present findings to the organization.
• Provide mentorship within the team and organization.
• Horizon scan for emergent methodologies that could add value to projects.
• Develop protocols for current and new NGS methods and lead associated R&D projects.
• Collaborate with other R&D sites and Data Science to develop new protocols for challenging target genes/DNA modalities.

Requirements

• A minimum of 5 years' experience in technically focused molecular biology and sequencing projects for method development in a commercial R&D or large project-based academic setting, ideally in non-model organisms.
• Strong understanding of metagenomic extraction methodologies across a range of sample types.
• Experience developing or applying high molecular weight (HMW) extraction methods.
• Track record in delivering molecular methods for DNA and RNA extraction and sequencing in end-to-end workflows.
• Proficiency in experimental design and statistical comparison of method performance.
• Ability to troubleshoot experimental results.
• Pro-active and motivated in developing new methods and continuous improvement.
• Experience working within multi-disciplinary teams to deliver projects.

Skills

• Metagenomic extraction
• DNA/RNA purification
• High molecular weight (HMW) extraction
• Short and long-read sequencing technologies
• Virology (extraction and sequencing)
• Experimental design
• Method development
• Next Generation Sequencing (NGS)
• Data analysis
• Protocol development

Location

• London, UK
• Boston, Massachusetts, USA

Work Type

• Laboratory based
• Full-time

Experience Level

• Minimum 5 years' experience

Benefits

• Competitive salary
• Equity
• Private healthcare with no medical history exclusions
• Carrot Fertility with IVF stipend
• Salary sacrifice pension
• Bike-to-work scheme
• Life insurance

About the Company

• Basecamp Research solves life science challenges using frontier AI models and ethically-sourced biological data.
• They collect and curate biological data through global partnerships, enabling the design of novel protein sequences and biological systems.
• The company has secured Series B and pre-Series C investment from NVIDIA.
• Recognized by Fast Company and Sifted AI100.
• A diverse, exciting, fun, and flexible workplace with a team of biologists, engineers, ML scientists, and more.
• United by a passion for discovering nature's solutions through biology, data, and AI.

Equal Opportunity

• Committed to equal opportunity employment regardless of ethnic or national origin, race, religion, sex, age, citizenship, sexual orientation, marital status, disability, gender identity or any other basis.
• Accommodations available for individuals with disabilities or additional needs.