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About the Role

Axsome Therapeutics is seeking an Associate Director, HEOR Analytics. This is a hands-on, technical role responsible for designing and executing real-world evidence (RWE) analyses using large-scale healthcare datasets. The role combines advanced statistical programming, study design, and analytical expertise to generate rigorous evidence supporting evidence generation priorities.

Responsibilities

• Lead development of analytical strategies supporting HEOR, Medical Affairs, and market access evidence generation
• Design appropriate methodologies including traditional statistical approaches and advanced analytics (e.g., survival analysis, comparative effectiveness, treatment patterns, healthcare resource utilization, machine learning where appropriate)
• Apply epidemiologic and statistical methodologies to address bias, confounding, and missing data in real-world datasets
• Contribute to protocol development, database specifications, and statistical analysis plans
• Ensure methodological rigor, reproducibility, and compliance with regulatory and industry standards
• Perform and oversee statistical programming and analysis using SAS, R, Python, and SQL
• Develop and validate analysis-ready datasets and analytic workflows from raw healthcare data sources
• Lead cohort identification using clinical coding systems (e.g., ICD, CPT, NDC)
• Support data acquisition strategy by identifying appropriate claims, EHR, and other real-world data sources
• Partner with IT and Commercial Operations on real world database ingestion into Axsome data ecosystem
• Translate analytical results into actionable insights for non-technical stakeholders via graphics, slides, and dashboards as appropriate
• Contribute to development of, abstracts, presentations, and manuscripts
• Support development of payer evidence and value dossiers
• Present findings to internal and external stakeholders including scientific meetings
• Partner with HEOR strategy leads and Medical Affairs teams, as well as Commercial and Market Access analytics as appropriate
• Translate business needs into analytical solutions
• Manage and oversee external vendors and CROs conducting HEOR/RWE analyses
• Serve as a technical leader in HEOR analytics and promote best practices
• Stay current with evolving RWE methodologies and analytics tools
• Contribute to continuous improvement of HEOR analytics processes and standards

Requirements

• PhD or Master’s degree in Biostatistics, Epidemiology, Health Economics, Data Science, or related quantitative field
• 5+ years of experience conducting analyses using real-world healthcare data (claims, EHR/EMR, registries)
• Ability to work on site Monday, Tuesday & Thursday
• Experience designing and executing observational and retrospective studies
• Track record of generating real-world evidence to support publications or market access
• Strong programming skills in SAS, R, Python, and/or SQL
• Expertise in statistical methods (e.g., regression, survival analysis, causal inference)
• Hands-on experience with large healthcare databases and data structures
• Experience with cohort construction and data transformation

Skills

• SAS
• R
• Python
• SQL
• Survival analysis
• Comparative effectiveness
• Treatment patterns
• Healthcare resource utilization
• Machine learning
• Epidemiologic methodologies
• Statistical methodologies
• Causal inference

Location

• New York City

Work Type

• On-site (at least three days per week)

Experience Level

• Associate Director
• 5+ years of experience

Education Level

• PhD or Master’s degree in Biostatistics, Epidemiology, Health Economics, Data Science, or related quantitative field

Salary/Compensations

• $175,000 - $195,000

Benefits

• Annual bonus
• Significant equity
• Generous benefits package

About the Company

• Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions.
• We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes.
• Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States.
• Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish.
• For more information, please visit us at www.axsome.com and follow us on LinkedIn and X.

Equal Opportunity

• Axsome is committed to equal employment opportunity and providing reasonable accommodations to applicants with physical and/or mental disabilities.
• We value and encourage diversity and solicit applications from all qualified applicants without regard to race, color, gender, sex, age, religion, creed, national origin, sexual orientation, gender identity, ancestry, citizenship, marital status, physical or mental disability, medical condition, veteran status, genetic information, or any other characteristic protected by federal, state, or local law.