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About the Role

Support the development, optimization, and transfer of GMP-compliant CAR T-cell manufacturing processes from leukapheresis material through final product cryopreservation. Execute hands-on cell therapy process development activities, including T-cell isolation, activation, genetic modification, expansion, harvesting, formulation, and cryopreservation using automated and semi-automated manufacturing platforms such as CliniMACS Plus, CliniMACS Prodigy, and G-Rex systems. Perform laboratory studies to evaluate process performance, scalability, robustness, and technology transfer readiness while maintaining aseptic techniques and compliance with GMP principles. Conduct analytical testing, including flow cytometry and cell-based assays, to assess cell phenotype, viability, potency, and function, and document results to support process characterization, continuous improvement, and manufacturing readiness.

Responsibilities

Execute hands-on cell therapy process development activities
Perform laboratory studies to evaluate process performance, scalability, robustness, and technology transfer readiness
Maintain aseptic techniques and compliance with GMP principles
Conduct analytical testing, including flow cytometry and cell-based assays
Document results to support process characterization, continuous improvement, and manufacturing readiness

Requirements

Master’s degree and the equivalent of eighteen (18) months of full-time professional research experience in a laboratory, clinical or scientific research environment
Bachelor’s degree and the equivalent of thirty (30) months of full-time professional research experience in a laboratory, clinical or scientific research environment
Degrees must be conferred by an accredited school, college, or university, or by an institution recognized by Roswell Park Comprehensive Cancer Center and/or Health Research Incorporated as adhering to acceptable educational standards
Familiarity with CAR T-cell manufacturing workflows, including leukapheresis processing, T-cell isolation, activation, gene modification, expansion, harvesting, formulation, and cryopreservation
Knowledge of commonly utilized tools in cell therapy or blood processing laboratories (examples CliniMACS Plus and CliniMACS Prodigy, Cocoon)
Familiarity with technical documentation, Standard Operating Procedures (SOP), Batch Record (BR) and report writing
Compliance with funding requirements such as time and effort reporting, grant deliverables, and contract deliverables is required

Skills

T-cell isolation
T-cell activation
Genetic modification
Cell expansion
Cell harvesting
Cell formulation
Cell cryopreservation
CliniMACS Plus
CliniMACS Prodigy
G-Rex systems
Aseptic techniques
GMP principles
Flow cytometry
Cell-based assays
Blood Processing techniques - Manual Ficoll
PCR/ qPCR

Location

First Shift (United States of America)

Work Type

Full time

Experience Level

18 months of full-time professional research experience (Master's degree)
30 months of full-time professional research experience (Bachelor's degree)
Experience in GMP manufacturing

Education Level

Master's degree
Bachelor's degree

Salary/Compensations

$62,514 - $78,846 annually

Benefits

Comprehensive benefits package

About the Company

Health Research, Inc. (HRI) Roswell Park Division
Center for Immunotherapy
Roswell Park Cancer Institute Corporation (RPCIC) and Health Research Inc. (HRI) Roswell Park Division believe that all persons are entitled to equal employment opportunities
RPCIC and HRI are committed to providing an environment where patients, families, employees and community are treated with courtesy and respect
We support an inclusive environment that nurtures the talents, skills and abilities of each individual to embody and reflect our core values: Innovation, Integrity, Teamwork, Commitment, Compassion and Respect
This is a grant-funded position
Health Research Inc. (HRI) Roswell Park Division participates in the E-Verify program

Equal Opportunity

We do not discriminate against our employees, applicants or job seekers because of their race, color, religion, sex, sexual orientation, gender identity or expression, national origin, creed, age, disability, pregnancy-related condition, military or veteran status, marital or familial status, domestic violence victim status, citizenship status, genetic information, individual’s relationship or association with a member of a protected category or any other protected group status as defined by law.
Affirmative Action/Equal Opportunity Employer/Qualified Individuals with Disabilities/Qualified Protected Veterans
RPCIC and HRI are committed to working with and providing reasonable accommodation to individuals with disabilities.