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About the Role

Execute the company's experimental plan in iPSC-based and primary cellular models, working closely with the scientific co-founders. The work spans three integrated cell systems: primary human astrocytes, iPSC-derived astrocyte–neuron co-culture, and iPSC-derived microglia. Own specific experimental arms, troubleshoot and optimize protocols, present data, and contribute to publications. Scope and ownership grow with demonstrated capability.

Responsibilities

Execute the company's experimental plan in iPSC-based and primary cellular models.
Work closely with the scientific co-founders who direct the research agenda.
Perform experiments using primary human astrocytes, including pharmacological lipid loading and ApoE genotype-stratified challenge studies.
Conduct functional cellular readouts of receptor signaling and metabolic output.
Utilize iPSC-derived astrocyte–neuron co-culture, including isogenic ApoE3/E4 model systems with functional, imaging, and mass spectrometry–based biomarker readouts.
Work with iPSC-derived microglia, including induction of disease-relevant lipid-handling states and evaluation of candidate therapeutic compounds.
Perform assays of intracellular lipid trafficking and clearance.
Own specific experimental arms.
Troubleshoot and optimize protocols.
Present data in internal review meetings.
Contribute as an author on publications emerging from the program.
Participate in scientific work on the computational side, in support of Fulcrum’s efforts and collaborations.

Requirements

PhD in cell biology, neuroscience, biochemistry, or related field with hands-on iPSC experience; OR MS with 5+ years industry bench experience running iPSC-based assays.
Demonstrated competence in iPSC maintenance and differentiation in at least one glial or neuronal lineage.
Fluency with confocal and/or high-content imaging, including quantitative analysis of cellular phenotypes.
Comfort with standard molecular and cell biology methods (qPCR, Western blot, ELISA, flow cytometry, siRNA transfection).
Bay Area-based or willing to relocate within 60 days.
Able to work on-site in South San Francisco.
Experience with iPSC microglia, or with co-culture and tri-culture systems.
Interest in lipid biology, cholesterol homeostasis, or neuroimmune mechanisms in neurodegeneration.
Receptor signaling assay experience.
Familiarity with mass spectrometry sample preparation or lipidomics data interpretation.

Skills

iPSC maintenance and differentiation
Glial or neuronal lineage differentiation
Confocal imaging
High-content imaging
Quantitative analysis of cellular phenotypes
qPCR
Western blot
ELISA
Flow cytometry
siRNA transfection
iPSC microglia
Co-culture systems
Tri-culture systems
Lipid biology
Cholesterol homeostasis
Neuroimmune mechanisms
Receptor signaling assays
Mass spectrometry sample preparation
Lipidomics data interpretation

Location

South San Francisco, CA

Work Type

Fully on-site
Contract role
Potential for transition to employee role
Full-time
Part-time

Experience Level

PhD with hands-on iPSC experience
MS with 5+ years industry bench experience running iPSC-based assays

Education Level

PhD in cell biology, neuroscience, biochemistry, or related field
MS

Salary/Compensations

Meaningful early-stage equity and contract rate commensurate with experience

Benefits

Integration with the hypothesis-generation layer of the company
See how computational target ID translates to bench experiments
Work directly with people doing computational target ID
Clear growth path to Scientist II / Senior Scientist roles
Authorship on publications
Meaningful early-stage equity

About the Company

Fulcrum Neuroscience is a biotech startup developing new therapeutic approaches to Alzheimer’s disease and other neurodegenerative conditions.
Utilizes a unique computational platform: the Brain Health and Neurodegeneration world model, reconciling over 1,800 literature and data sources, and an underlying AI-enabled, digital twin computational engine.
Platform enables exploration of target and therapeutic alternatives, identification of biomarker patterns, and design of lab and clinical experiments.
Recently established a new laboratory in South San Francisco, CA.
Building a team to develop and execute an ambitious research plan for the development of new classes of Alzheimer’s therapeutics.
Experimental work and computational work proceed in tandem, each informing the other.

Equal Opportunity

Direct applicants only, please. We are not working with staffing agencies or third-party recruiters for this contract opportunity and are not accepting agency-submitted candidates.