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About the Role

Seeking a motivated Research Associate for the Quality Control team to perform and interpret in vitro potency and characterization assays. This bench-focused role involves maintaining cell lines and reference standards, analyzing data, and helping build robust QC methods as the platform advances.

Responsibilities

• Perform routine in vitro QC release and characterization assays, including cell-based potency/functional assays and ligand-binding ELISAs.
• Prepare reference standards, standard curves, and serial sample dilutions; interpolate concentrations and determine relative potency.
• Apply and monitor assay acceptance criteria and system-suitability metrics.
• Execute assays under aseptic technique; troubleshoot assay performance and contribute to method optimization.
• Maintain, passage, and cryopreserve mammalian reporter and production cell lines.
• Perform routine cell-health checks and mycoplasma testing.
• Manage cell banks and assay reagent inventory.
• Maintain accurate and detailed laboratory records.
• Author and review SOPs, analytical methods, and qualification/validation reports.
• Partner with Process Development and Formulation to support research and development efforts.

Requirements

• BS or MS in Biology, Biochemistry, Molecular or Cell Biology, Bioengineering, or a related life-science discipline.
• Bachelor’s degree with 4–5 years of relevant laboratory experience, OR Master’s degree with 1–2 years of relevant laboratory experience.
• Hands-on experience with mammalian cell culture and aseptic technique.
• Experience with cell-based potency/functional assays and/or plate-based biochemical assays such as ELISA.
• Proficiency analyzing dose-response data and fitting standard and potency curves using common scientific data-analysis software (e.g., GraphPad Prism, SoftMax Pro, or equivalent).
• Working knowledge of QC principles: assay qualification/validation, acceptance criteria, controls, and metrics.
• Strong analytical thinking and problem-solving skills.
• Excellent communication and technical writing abilities.
• Ability to thrive in a fast-paced, startup environment.
• Self-motivated, adaptable, and eager to learn.

Skills

• Reporter-gene / luciferase assays
• Ligand-binding ELISAs
• Plate-based biochemical assays
• Dose-response data analysis
• GraphPad Prism
• SoftMax Pro
• Assay qualification/validation
• Aseptic technique
• Mammalian cell culture
• Cell-based potency assays
• Functional assays
• Method optimization
• Technical writing

Location

• South San Francisco, California

Work Type

• Onsite
• Full-time

Experience Level

• 4-5 years relevant laboratory experience (with BS)
• 1-2 years relevant laboratory experience (with MS)

Education Level

• BS or MS in Biology, Biochemistry, Molecular or Cell Biology, Bioengineering, or a related life-science discipline

Salary/Compensations

• $40-$50 per hour

Benefits

• Competitive salary
• Equity
• Benefits

About the Company

• Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ platform.
• PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome.
• Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.

Equal Opportunity

• We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.