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About the Role
Addition Therapeutics is seeking a Scientist / Senior Scientist to lead the design and execution of in vivo CAR-T studies. This role focuses on experimental execution, animal handling, model development, and data interpretation, advancing CAR-T programs through integrated efficacy and cellular/molecular readouts.
Responsibilities
- Develop and optimize in vivo models to evaluate CAR-T efficacy, tumor killing, expansion, persistence, and activity.
- Design and execute in vivo CAR-T studies in appropriate humanized mouse models.
- Perform animal handling and procedures, including dosing, blood collection, tissue and tumor harvest, and sample processing for downstream analyses.
- Perform and interpret multiparameter flow cytometry analyses to characterize CAR-T cells and immune populations.
- Support molecular and protein-based analyses, as needed.
- Integrate in vivo efficacy, cellular, and molecular readouts to guide program decisions.
- Develop study protocols and contribute to IACUC amendments, animal welfare, compliance, and study documentation.
- Manage external studies with CROs, including vendor selection, protocol design, oversight, and data review, analysis, and interpretation.
- Troubleshoot experimental challenges and drive improvements in study execution and model performance.
- Maintain detailed and organized study records; contribute to study reports and presentations.
Requirements
- PhD in Biology, Pharmacology, Immunology, Cancer Biology, or related field, with 4-6 years of relevant research or industry experience.
- Demonstrated hands-on in vivo pharmacology experience, including animal handling, dosing, tissue collection, and necropsy.
- Experience with CAR-T in vivo models, preferably humanized mice and tumor models.
- Experience assessing in vivo tumor killing/efficacy and CAR-T expansion or persistence.
- Proficiency with flow cytometry and data analysis.
- Experience managing in vivo studies at CROs.
- Strong experimental, analytical, troubleshooting, organizational, and communication skills.
- Meticulous attention to detail and strong documentation including use of electronic notebook for record keeping.
- Team player who fosters a culture of collaboration, accountability, and scientific excellence, and who thrives in a fast-moving, results-oriented startup environment.
- A self-motivated, driven individual with a passion to learn and can-do attitude.
Skills
- CAR-T
- in vivo pharmacology
- animal handling
- dosing
- tissue collection
- necropsy
- humanized mouse models
- tumor models
- flow cytometry
- data analysis
- ddPCR
- ELISA/MSD
- molecular assays
- protein assays
- experimental skills
- analytical skills
- troubleshooting skills
- organizational skills
- communication skills
- documentation
- electronic notebook
- collaboration
- accountability
- scientific excellence
Location
- South San Francisco, California
Work Type
- Full-time
Experience Level
- 4-6 years of relevant research or industry experience
- Scientist / Senior Scientist
Education Level
- PhD in Biology, Pharmacology, Immunology, Cancer Biology, or related field
Salary/Compensations
- $116,000-$166,000
About the Company
- Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies utilizing its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform.
- PRINT™ redefines genetic medicine by enabling development of RNA-only therapeutics capable of inserting any genetic element into specific safe harbor sites within the genome.
- Operating from state-of-the-art labs in South San Francisco, our team of experienced scientists and drug developers is leading scientific breakthroughs while cultivating a vibrant, dynamic culture committed to profoundly impacting patient lives.
Equal Opportunity
- We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.