About the Role
We are seeking a creative and highly motivated Research Associate to join our Clinical Virology team at our South San Francisco location. You will work closely with members of the clinical virology team to support antiviral drug discovery and development.
Responsibilities
- Performing testing of clinical isolates to assess viral replication, fitness, and drug susceptibility
- Designing and executing in vitro resistance selection experiments
- Characterizing resistance-associated substitutions through both phenotypic and genotypic analyses
- Generating and evaluating recombinant viruses carrying clinically relevant mutations
- Performing viral propagation, titration, infectivity, and replication assays
- Conducting nucleic acid extraction, qPCR, RT-qPCR, and related molecular assays
- Collaborating with senior research members and cross-functional teams to analyze data, interpret results, and prepare technical reports and study summaries
- Effectively supporting multiple projects and learning new techniques to support novel exploratory discovery work, as needed
- Utilizing data analysis software and MS Office applications
- Participating in general lab maintenance including reagent preparation, ordering of general lab supplies, and maintenance of equipment
Requirements
- Must be comfortable working in a BSL2 setting with potentially infectious agents
- Demonstrated expertise in ensuring good laboratory practices and BSL2 standards
- Ability to present experimental rationale and data to other scientists
- Motivated, and proactive molecular virologist and/or cell biologist with desire to work in a fast-paced, dynamic environment
- Familiarity with Microsoft Office applications, GraphPad Prism, molecular cloning programs, and scientific informatics tools for data input, analysis, and management
Skills
- Assay development
- Virology
- Cell biology
- Molecular biology techniques
- Viral stock preparation
- Titration
- Replication assays
- In vitro resistance selection
- (RT)-PCR
- (RT)qPCR
- Sanger sequencing
- NGS
- Molecular cloning
- Mutagenesis
- Data analysis
- Data visualization
- Microsoft Office applications
- GraphPad Prism
- Molecular cloning programs
- Scientific informatics tools
Location
- South San Francisco, CA
Work Type
- Regular
- Full-time
Experience Level
- 2 - 5 years of relevant experience in industrial or academic settings
- Preference given to experience in biomarker and translational research activities
Education Level
- Sc./M.S. or equivalent degree in Virology, Molecular Biology, Cell Biology, or relevant scientific discipline
Salary/Compensations
- $87,000 - $91,260 annualized
About the Company
- Assembly Bio (NASDAQ: ASMB) is an ambitious biopharmaceutical company with cutting-edge therapeutic candidates capable of improving the lives of millions living with devastating viral and liver diseases.
- We have multiple ongoing clinical programs focused on the development of novel treatments for herpesviruses, hepatitis delta virus (HDV), cholestatic liver diseases and hepatitis B virus (HBV).
- Further, our research organization is dedicated to the discovery of new therapies to change the treatment paradigm for individuals living with serious viral and liver diseases.
- We pride ourselves on creating a culture and work environment that is scientifically driven, ambitious, and collaborative.
- We encourage diversity of thought that leads to great innovation and are looking to add great people to our dynamic team who are driven to transform the lives of patients.
- We set our sights high—and pursue our goals with determination.
- Our unique organization stands ready to welcome talented, motivated individuals, who share our ambitions.
Equal Opportunity
- As an equal opportunity employer, we are committed to diversity and inclusion and will not tolerate discrimination and harassment of any kind.
- All employment decisions are based on business needs, job requirements and individual qualifications, without regard to race, color, religion or belief, national, social or ethnic origin, sex (including pregnancy), age, physical, mental or sensory disability, HIV status, sexual orientation, gender identity and/or expression, marital, civil union or domestic partnership status, past or present military service, family medical history or genetic information, family or parental status, or any other status protected by the laws or regulations in the locations where we operate.
