Impress employers and recruiters.
Choose from hundreds of resume examples.

Target Resume Now

About the Role

As a Scientist in the Delivery team, you will develop and evaluate non-viral gene delivery approaches that enable the expression and function of novel molecular biosensors and actuators of neural activity in preclinical models. Your work will serve as the critical bridge between molecular engineering and in vivo functionality and enable the ultimate clinical translation of molecular BCI. You will collaborate closely with protein engineers, cell and synthetic biologists, data scientists, physicists and neurobiologists.

Responsibilities

Identify and secure access to non-viral delivery technologies through collaborations, material transfer agreements, or in-licensing.
Formulate, adapt, and characterize LNPs, polymeric nanoparticles, and other non-viral vehicles for delivery of nucleic acid payloads to the central nervous system.
Define success criteria for efficacy and tolerability, and develop necessary assays and readouts.
Design, run, and interpret in vivo studies in rodents and large animal models, comparing candidate technologies.
Evaluate approaches pairing non-viral technologies with ultrasound-mediated blood-brain barrier opening.
Assess durability of expression and potential for repeat dosing, considering manufacturability and cost.
Collaborate with molecular engineering and neurobiology colleagues on payload design and expression requirements.
Operate independently, drive projects to completion, and mentor research associates.

Requirements

Ph.D. or equivalent experience leading research projects end-to-end in bioengineering, chemical engineering, drug delivery, neuroscience, molecular biology or a related field.
Prior hands-on experience with non-viral delivery vehicles including lipid nanoparticles or polymeric nanoparticles.
Demonstrated expertise in developing, optimizing, or critically evaluating gene delivery modalities.
Experience designing and executing in vivo studies and interpreting delivery and expression results.
Experience advancing a delivery technology through preclinical translation or into the clinic.
Experience working on unusual or complex delivery-related problems.
Experience working on multidisciplinary teams, collaborating and communicating with experts across disciplines.
Desire to be part of a fast-paced team working on frontier scientific and technical problems.

Skills

Non-viral delivery vehicles
Lipid nanoparticles
Polymeric nanoparticles
Gene delivery modalities
In vivo studies
Preclinical translation
Multidisciplinary collaboration
Communication

Location

Remote

Work Type

Full-time

Experience Level

Ph.D. or equivalent experience

Education Level

Ph.D.

About the Company

Merge Labs is a frontier research lab with the mission of bridging biological and artificial intelligence to maximize human ability, agency and experience.
We’re pursuing this goal by developing fundamentally new approaches to brain-computer interfaces that interact with the brain at high bandwidth, integrate with advanced AI, and are ultimately safe and accessible for anyone to use.
The Delivery team develops the viral and non-viral delivery technologies that enable Merge's next-generation neurotechnology platform.
By partnering closely with bioengineering, neuroscience, and in vivo teams, we create delivery systems that support rapid preclinical testing while advancing the platform toward safe and effective human translation.
We work across disciplines to come up with creative ideas and solve some of the most challenging problems in biotechnology.

Equal Opportunity

Merge Labs does not discriminate on the basis of race, color, religion, national origin, age, sex, sexual orientation, gender, gender identity, gender expression, marital status, physical or mental disability, medical condition, genetic information, family status, ancestry, citizenship, U.S. military (state and federal) and veteran status, or any other legally protected status.
It is our intention that all applicants be given equal opportunity and that selection decisions are based on job related factors.
We are an equal opportunity employer.
Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
We are committed to providing reasonable accommodations to applicants with disabilities, and requests can be made by emailing accommodations@merge.io.