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About the Role
We are seeking an experienced Senior Scientist to lead the development of next-generation MRD assays from concept through clinical lab implementation. This individual will drive technical strategy, experimental design, and scientific decision-making across assay development, automation, and workflow optimization. The ideal candidate has direct experience in NGS-based oncology diagnostics and a proven track record of developing clinical assays in regulated environments through cross-functional leadership and scientific innovation.
Responsibilities
- Lead the development, verification, and transfer of NGS-based MRD assays from concept through clinical lab implementation.
- Independently develop workflows suitable for clinical operations, including automation, QC, throughput requirements, and LIMS integration.
- Conceive innovative solutions and develop rigorous experimental strategies to advance assay performance, sensitivity, robustness, scalability, and operational readiness.
- Design and execute feasibility, optimization, and verification studies, with independent ownership of objectives, study design, planning, execution, and analysis guided by systematic application of biochemistry and bioinformatic principles.
- Author and review protocols, SOPs, reports, requirements, risk assessments, and design control documentation supporting product development and regulatory compliance.
- Serve as a subject matter expert in NGS, oncology genomics, and ctDNA/MRD technologies, leading troubleshooting and resolution of complex technical challenges.
- Collaborate cross-functionally with Bioinformatics, Data Science, Operations, Clinical Laboratory, Automation, SW/LIMS, Quality, and Regulatory teams to develop and implement robust diagnostic products.
- Support technology transfer, assay implementation, and commercialization activities, including training and mentoring laboratory personnel and junior scientists.
Requirements
- NGS assay expert with deep theoretical and hands-on knowledge of the biochemistry underlying multi-component molecular biology methods at the sample preparation and assay level.
- Proven track record of successfully troubleshooting and optimizing molecular biology techniques/assays in a developed workflow.
- Bench scientist eager to participate directly in laboratory work independently and in cooperation/coordination with others.
- Must be able to mentor others and effectively manage (design, monitor, complete, troubleshoot) laboratory project tasks performed in the hands of others.
- Rigorous and skilled in NGS data analysis, with command of common and assay-specific metrics and excellent data analysis and visualization skills using common statistical methods and software (JMP, R, Python).
- Successful product developer with experience writing requirements and systematically building products under global PDP.
- Innovative technical leader eager to tackle complex scientific programs and generate solutions to challenging technical problems.
- Team player who elevates performance within and across functions through technical collaboration, mentorship of junior scientists, and positive attitude.
- Practical developer with the ability to evaluate multiple technical variables and translate data into actionable decisions that consider program priorities, timelines, and cross-functional requirements.
- Clear and effective communicator with exceptional written and verbal communication skills.
- Flexible and open-minded contributor in the face of shifting resources & priorities.
- Passionate about developing diagnostics that improve outcomes for cancer patients.
Skills
- NGS
- Oncology Genomics
- ctDNA/MRD technologies
- NGS data analysis
- JMP
- R
- Python
- Cancer genomics
- Liquid biopsy
- ctDNA
- MRD diagnostics
- LDT product development
- Design control
- Quality system
- CAP/CLIA
- NYSDOH
Location
- Onsite
Work Type
- Full-time
Experience Level
- Senior Scientist
- 6 – 7 years of post-doctoral and relevant industry experience focused on NGS wet-lab experimentation, preferably in a Product Development environment
- Extensive experience developing NGS-based assays for clinical, diagnostic, or regulated applications
- Experience with automation and design and development of high-throughput workflows
- Strong background in cancer genomics, liquid biopsy, ctDNA, or related molecular diagnostic technologies.
- Direct experience developing MRD or liquid biopsy diagnostics a plus.
- Proven ability to independently lead complex technical projects.
Education Level
- PhD in Molecular Biology, Genetics, Biochemistry, or a related field.
Salary/Compensations
- $150,000—$170,000 USD
Benefits
- Competitive compensation and benefits
About the Company
- Veracyte is a global diagnostics company whose vision is to transform cancer care for patients all over the world.
- We empower clinicians with the high-value insights they need to guide and assure patients at pivotal moments in the race to diagnose and treat cancer.
- Our Veracyte Diagnostics Platform delivers high-performing cancer tests that are fueled by broad genomic and clinical data, deep bioinformatic and AI capabilities, and a powerful evidence-generation engine, which ultimately drives durable reimbursement and guideline inclusion for our tests, along with new insights to support continued innovation and pipeline development.
- For more information, please visit www.veracyte.com or follow us on LinkedIn or X (Twitter).
Equal Opportunity
- Veracyte, Inc. is an Equal Opportunity Employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability status.
- Veracyte participates in E-Verify in the United States.
- View our CCPA Disclosure Notice
- If you receive any suspicious alerts or communications through LinkedIn or other online job sites for any position at Veracyte, please exercise caution and promptly report any concerns to careers@veracyte.com