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About the Role

Addition Therapeutics is seeking a motivated Research Associate / Senior Research Associate (Contract) to join our Analytical Development team and help advance the development of next-generation RNA therapeutics. In this role, you will perform analytical testing of plasmid DNA, RNA, and lipid nanoparticle (LNP) formulations while contributing to the development, optimization, qualification, and transfer of analytical methods that support process development and preclinical manufacturing.

Responsibilities

Perform routine QC testing and analytical characterization of plasmid DNA, RNA, and RNA-loaded LNPs.
Develop, optimize, and execute analytical methods to assess RNA identity, purity, integrity, capping efficiency, poly(A) tail length, process impurities (e.g., residual plasmid DNA, proteins, dsRNA), and LNP physicochemical properties.
Analyze, interpret, and document experimental data in electronic laboratory notebooks (ELNs), and communicate findings to cross-functional teams.
Investigate analytical deviations, troubleshoot assays and instrumentation, and support technical investigations.
Author and maintain SOPs, analytical methods, protocols, and technical reports.
Support analytical method qualification, validation, and technology transfer activities.
Maintain laboratory equipment, inventory, and an organized laboratory environment.

Requirements

Experience characterizing plasmid DNA, RNA, lipid nanoparticles, and/or related process impurities.
Strong analytical, problem-solving, organizational, and technical communication skills.
Ability to work independently and collaboratively in a fast-paced, team-oriented environment.

Skills

HPLC (CAD, UV, or MS)
Capillary electrophoresis
qPCR
ELISA
Plate-based biochemical assays
Analytical method development
Analytical method qualification
Analytical method validation
Technology transfer
RNA therapeutics
In vitro transcription (IVT)
Lipid nanoparticle (LNP) drug products

Location

South San Francisco, California

Work Type

Contract

Experience Level

2+ years of relevant industry experience

Education Level

BS or MS in Chemistry, Molecular Biology or a related scientific discipline

About the Company

Addition Therapeutics is at the forefront of biotechnology innovation, advancing transformative therapies through its proprietary PRINT™ (Precise RNA-mediated Insertion of Transgenes) platform.
PRINT™ redefines genetic medicine by enabling the development of RNA-only therapeutics capable of inserting genetic elements into specific safe harbor sites within the genome.
Operating from state-of-the-art laboratories in South San Francisco, our team of experienced scientists and drug developers is driving scientific breakthroughs while cultivating a collaborative, dynamic culture committed to making a profound impact on patients' lives.

Equal Opportunity

Addition Therapeutics is an Equal Opportunity Employer. We are committed to creating an inclusive workplace and consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, disability, protected veteran status, or any other characteristic protected by applicable law.